Seroatlas · Human Serome Atlas

CMAHP

Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase

Also known as: CMAH_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y471
Gene: CMAHP
Canonical length: 501 aa

OverviewNCBI Gene

No narrative summary is available for CMAHP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>Q9Y471|CMAHP
     1  MDENNGLLLL ELNPPNPWDL QPRSPEELAF GEVQITYLTH ACMDLKLGDK RMVFDPWLIG
    61  PAFARGWWLL HEPPSDWLER LCQADLIYIS HLHSDHLSYP TLKKLAGRRP DIPIYVGNTE
   121  RPVFWNLNQS GVQLTNINVV PFGIWQQVDK NLRFMILMDG VHPEMDTCII VEYKGHKILN
   181  IVDCTRPNGG RLPMKVALMM SDFAGGASGF PMTFSGGKFT EEWKAQFIKT ERKKLLNYKA
   241  RLVKNLQPRI YCPFAGYFVE SHPSDKYIKE TNTKNDPNEL NNLIKKNSDV ITWTPRPGAT
   301  LDLGRMLKDR TDSKGIIEPP EGTKIYKDSW DFEPYLEILN AALGDEIFLH SSWIKEYFTW
   361  AGFKDYNLVV RMIETDEDFN PFPGGYDYLV DFLDLSFPKE RPQREHPYEE IHSRVDVIRH
   421  VVKNGLLWDE LYIGFQTRLQ RDPDIYHHLF WNHFQIKLPL TPPNWKSFLM CCEQNGPVIL
   481  QFSTERTNEP NRNKFSVENK A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMAHP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of Wnt signaling pathway
CMP-N-acetylneuraminate metabolic process

Molecular functions

CMP-N-acetylneuraminate monooxygenase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Cytidine monophosphate-N-acetylneuraminic acid hydroxylase
Beta-lactamase superfamily domain

KeywordsUniProt

Cytoplasm

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMAHP as an antibody target. Whether an autoantibody or antibody against CMAHP could matter depends on whether native CMAHP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMAHP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CMAHP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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