Seroatlas · Human Serome Atlas

CLVS2

Clavesin-2

Also known as: bA160A10.4, C6orf212, C6orf213, CLVS2_HUMAN, RLBP1L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SYC1
Gene: CLVS2
Ensembl: ENSG00000146352
Chromosome: 6
Canonical length: 327 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that belongs to the SEC14/CRAL-TRIO family of proteins. A similar protein in rat is thought to function in the endosomal pathway between early endosomes and mature lysosomes. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q5SYC1|CLVS2
     1  MTHLQAGLSP ETLEKARLEL NENPDTLHQD IQEVRDMVIT RPDIGFLRTD DAFILRFLRA
    61  RKFHHFEAFR LLAQYFEYRQ QNLDMFKSFK ATDPGIKQAL KDGFPGGLAN LDHYGRKILV
   121  LFAANWDQSR YTLVDILRAI LLSLEAMIED PELQVNGFVL IIDWSNFTFK QASKLTPSML
   181  RLAIEGLQDS FPARFGGIHF VNQPWYIHAL YTVIRPFLKE KTRKRIFLHG NNLNSLHQLI
   241  HPEILPSEFG GMLPPYDMGT WARTLLDHEY DDDSEYNVDS YSMPVKEVEK ELSPKSMKRS
   301  QSVVDPTVLK RMDKNEEENM QPLLSLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLVS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 17 nTPM
cerebral cortex: 8.6 nTPM
retina: 7.6 nTPM
basal ganglia: 3.8 nTPM
prostate: 2.8 nTPM
hippocampal formation: 2.7 nTPM

Single-cell type

corticotrophs: 222 nCPM
brain excitatory neurons: 181 nCPM
müller glia: 153 nCPM
brain inhibitory neurons: 140 nCPM
retinal ganglion cells: 124 nCPM
gonadotrophs: 94 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 113 nTPM
cerebral cortex: 46 nTPM
hypothalamus: 41 nTPM
basal ganglia: 36 nTPM
pons: 36 nTPM
white matter: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.01
gnomAD missense Z: 1.8
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lysosome organization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLVS2 as an antibody target. Whether an autoantibody or antibody against CLVS2 could matter depends on whether native CLVS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLVS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLVS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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