Seroatlas · Human Serome Atlas

CLVS1

Clavesin-1

Also known as: C6orf212L, CLVS1_HUMAN, CRALBPL, MGC34646, RLBP1L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IUQ0
Gene: CLVS1
Ensembl: ENSG00000177182
Chromosome: 8
Canonical length: 354 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables phosphatidylinositol-3,5-bisphosphate binding activity. Predicted to be involved in lysosome organization. Located in endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q8IUQ0|CLVS1
     1  MGPVSLLPKY QKLNTWNGDL AKMTHLQAGL SPETIEKARL ELNENPDVLH QDIQQVRDMI
    61  ITRPDIGFLR TDDAFILRFL RARKFHQADA FRLLAQYFQY RQLNLDMFKN FKADDPGIKR
   121  ALIDGFPGVL ENRDHYGRKI LLLFAANWDQ SRNSFTDILR AILLSLEVLI EDPELQINGF
   181  ILIIDWSNFS FKQASKLTPS ILKLAIEGLQ DSFPARFGGV HFVNQPWYIH ALYTLIKPFL
   241  KDKTRKRIFL HGNNLNSLHQ LIHPEFLPSE FGGTLPPYDM GTWARTLLGP DYSDENDYTH
   301  TSYNAMHVKH TSSNLERECS PKLMKRSQSV VEAGTLKHEE KGENENTQPL LALD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLVS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 8.6 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.6 nTPM
basal ganglia: 7.4 nTPM
cerebral cortex: 6 nTPM
hypothalamus: 5.6 nTPM
retina: 4.8 nTPM
amygdala: 4.4 nTPM

Single-cell type

müller glia: 200 nCPM
brain inhibitory neurons: 200 nCPM
other brain neurons: 181 nCPM
ependymal cells: 150 nCPM
gonadotrophs: 149 nCPM
lactotrophs: 147 nCPM

Immune cell

basophil: 0.9 nTPM
neutrophil: 0.6 nTPM
naive B-cell: 0.5 nTPM
NK-cell: 0.4 nTPM
memory B-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM

Brain region

cerebellum: 30 nTPM
hypothalamus: 23 nTPM
cerebral cortex: 23 nTPM
basal ganglia: 21 nTPM
pons: 18 nTPM
white matter: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.85
gnomAD missense Z: 1.41
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lysosome organization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLVS1 as an antibody target. Whether an autoantibody or antibody against CLVS1 could matter depends on whether native CLVS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLVS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLVS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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