CLUL1
Clusterin-like protein 1
Also known as: CLUL1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15846
- Gene
- CLUL1
- Ensembl
- ENSG00000079101
- Chromosome
- 18
- Canonical length
- 466 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Endoplasmic reticulum,Plasma membrane
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
Predicted to enable misfolded protein binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
466 residues, UniProt reviewed canonical sequence.
>Q15846|CLUL1
1 MKPPLLVFIV CLLWLKDSHC APTWKDKTAI SENLKSFSEV GEIDADEEVK KALTGIKQMK
61 IMMERKEKEH TNLMSTLKKC REEKQEALKL LNEVQEHLEE EERLCRESLA DSWGECRSCL
121 ENNCMRIYTT CQPSWSSVKN KIERFFRKIY QFLFPFHEDN EKDLPISEKL IEEDAQLTQM
181 EDVFSQLTVD VNSLFNRSFN VFRQMQQEFD QTFQSHFISD TDLTEPYFFP AFSKEPMTKA
241 DLEQCWDIPN FFQLFCNFSV SIYESVSETI TKMLKAIEDL PKQDKAPDHG GLISKMLPGQ
301 DRGLCGELDQ NLSRCFKFHE KCQKCQAHLS EDCPDVPALH TELDEAIRLV NVSNQQYGQI
361 LQMTRKHLED TAYLVEKMRG QFGWVSELAN QAPETEIIFN SIQVVPRIHE GNISKQDETM
421 MTDLSILPSS NFTLKIPLEE SAESSNFIGY VVAKALQHFK EHFKTWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CLUL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 276 nTPM
Expression across tissuesHPA
Tissue
- retina: 276 nTPM
- choroid plexus: 27 nTPM
- prostate: 7.8 nTPM
- thyroid gland: 5.7 nTPM
- kidney: 4.9 nTPM
- cerebral cortex: 4.1 nTPM
Single-cell type
- rod photoreceptor cells: 405 nCPM
- prostatic glandular cells: 31 nCPM
- retinal ganglion cells: 31 nCPM
- retinal pigment epithelial cells: 30 nCPM
- müller glia: 29 nCPM
- corticotrophs: 22 nCPM
Immune cell
- neutrophil: 0.3 nTPM
- T-reg: 0.3 nTPM
- plasmacytoid DC: 0.2 nTPM
- basophil: 0.1 nTPM
- memory B-cell: 0.1 nTPM
- myeloid DC: 0.1 nTPM
Brain region
- white matter: 25 nTPM
- choroid plexus: 20 nTPM
- basal ganglia: 18 nTPM
- cerebral cortex: 16 nTPM
- thalamus: 14 nTPM
- hypothalamus: 14 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.31
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.64
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CLUL1 as an antibody target. Whether an autoantibody or antibody against CLUL1 could matter depends on whether native CLUL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CLUL1 is annotated as secreted, so native CLUL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CLUL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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