CLUHP3
Putative protein CLUHP3
Also known as: CLUP3_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for CLUHP3 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
147 residues, UniProt reviewed canonical sequence.
>Q96NS8|CLUHP3
1 MFLNGNCLET LKKKEPEGGR RRLSHPGNMG WMRPSQETTP PDRSHHSGFG LFCGDPGPEI
61 EPFSLWVFPQ EMVLEIHQLF MDHEYPCHHI TSHCTWVAAH WTTSQSCAAW QGCRRACCST
121 WWKSPAQCTR PTVMSATFET AQEPGPSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CLUHP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CLUHP3 as an antibody target. Whether an autoantibody or antibody against CLUHP3 could matter depends on whether native CLUHP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CLUHP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CLUHP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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