Seroatlas · Human Serome Atlas

CLPSL2

Colipase-like protein 2

Also known as: C6orf126, COLL2_HUMAN, dJ510O8.5, UNQ3045

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWE3
Gene: CLPSL2
Ensembl: ENSG00000196748
Chromosome: 6
Canonical length: 100 aa
Protein class: Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Predicted to enable enzyme activator activity. Predicted to be involved in response to food. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

100 residues, UniProt reviewed canonical sequence.

>Q6UWE3|CLPSL2
     1  MAAALALVAG VLSGAVLPLW SALPQYKKKI TDRCFHHSEC YSGCCLMDLD SGGAFCAPRA
    61  RITMICLPQT KGATNIICPC RMGLTCISKD LMCSRRCHMI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLPSL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 501 nTPM

Expression across tissuesHPA

Tissue

epididymis: 501 nTPM
pancreas: 5.2 nTPM
salivary gland: 1.6 nTPM
cerebral cortex: 0.7 nTPM
seminal vesicle: 0.7 nTPM
breast: 0.4 nTPM

Single-cell type

epididymal principal cells: 2,401 nCPM
epididymal efferent duct absorptive cells: 27 nCPM
epididymal basal cells: 17 nCPM
pancreatic acinar cells: 9.7 nCPM
epididymal clear cells: 8.2 nCPM
breast hormone-responsive cells: 5.1 nCPM

Immune cell

plasmacytoid DC: 0.4 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hippocampal formation: 0.7 nTPM
cerebral cortex: 0.6 nTPM
basal ganglia: 0.4 nTPM
hypothalamus: 0.4 nTPM
midbrain: 0.4 nTPM
amygdala: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0.19
gnomAD missense Z: 0.42
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

enzyme activator activity

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Colipase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLPSL2 as an antibody target. Whether an autoantibody or antibody against CLPSL2 could matter depends on whether native CLPSL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLPSL2 is annotated as secreted, so native CLPSL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CLPSL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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