Seroatlas · Human Serome Atlas

CLPSL1

Colipase-like protein 1

Also known as: C6orf127, COLL1_HUMAN, dJ510O8.6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2RUU4
Gene: CLPSL1
Ensembl: ENSG00000204140
Chromosome: 6
Canonical length: 121 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Predicted to enable enzyme activator activity. Predicted to be involved in response to food. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>A2RUU4|CLPSL1
     1  MMLPQWLLLL FLLFFFLFLL TRGSLSPTKY NLLELKESCI RNQDCETGCC QRAPDNCESH
    61  CAEKGSEGSL CQTQVFFGQY RACPCLRNLT CIYSKNEKWL SIAYGRCQKI GRQKLAKKMF
   121  F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLPSL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 573 nTPM

Expression across tissuesHPA

Tissue

epididymis: 573 nTPM
pancreas: 165 nTPM
breast: 4 nTPM
hippocampal formation: 2.6 nTPM
seminal vesicle: 2.2 nTPM
cerebral cortex: 1.6 nTPM

Single-cell type

epididymal principal cells: 1,181 nCPM
pancreatic acinar cells: 347 nCPM
epididymal basal cells: 17 nCPM
epididymal clear cells: 16 nCPM
adrenal medulla cells: 11 nCPM
breast lactating cells: 7.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 5.5 nTPM
hippocampal formation: 4 nTPM
basal ganglia: 1.8 nTPM
white matter: 1.5 nTPM
amygdala: 0.7 nTPM
hypothalamus: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

enzyme activator activity

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Colipase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLPSL1 as an antibody target. Whether an autoantibody or antibody against CLPSL1 could matter depends on whether native CLPSL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLPSL1 is annotated as secreted, so native CLPSL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CLPSL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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