Seroatlas · Human Serome Atlas

CLPS

Colipase

Also known as: COL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04118
Gene
CLPS
Ensembl
ENSG00000137392
Chromosome
6
Canonical length
112 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to digestive system

OverviewNCBI Gene

The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>P04118|CLPS
     1  MEKILILLLV ALSVAYAAPG PRGIIINLEN GELCMNSAQC KSNCCQHSSA LGLARCTSMA
    61  SENSECSVKT LYGIYYKCPC ERGLTCEGDK TIVGSITNTN FGICHDAGRS KQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLPS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
246,874 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 246,874 nTPM
  • ovary: 62 nTPM
  • heart muscle: 43 nTPM
  • salivary gland: 39 nTPM
  • duodenum: 38 nTPM
  • adipose tissue: 26 nTPM

Single-cell type

  • pancreatic acinar cells: 123,993 nCPM
  • pancreatic duct cells: 172 nCPM
  • neuroendocrine cells: 39 nCPM
  • monocytes: 29 nCPM
  • mast cells: 21 nCPM
  • pancreatic islet cells: 15 nCPM

Immune cell

  • neutrophil: 0.5 nTPM
  • eosinophil: 0.2 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebral cortex: 5.1 nTPM
  • hippocampal formation: 3.9 nTPM
  • basal ganglia: 3.3 nTPM
  • thalamus: 2.7 nTPM
  • white matter: 2.6 nTPM
  • medulla oblongata: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0.01
gnomAD missense Z
0.38
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Colipase
  • Colipase, N-terminal
  • Colipase, C-terminal
  • Colipase, conserved site
  • Colipase, chordates
  • Colipase, N-terminal domain
  • Colipase, C-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLPS as an antibody target. Whether an autoantibody or antibody against CLPS could matter depends on whether native CLPS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLPS is annotated as secreted, so native CLPS circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CLPS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLPS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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