Seroatlas · Human Serome Atlas

CLMP

CXADR-like membrane protein

Also known as: ACAM, ASAM, CLMP_HUMAN, FLJ22415

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H6B4
Gene
CLMP
Ensembl
ENSG00000166250
Chromosome
11
Canonical length
373 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>Q9H6B4|CLMP
     1  MSLLLLLLLV SYYVGTLGTH TEIKRVAEEK VTLPCHHQLG LPEKDTLDIE WLLTDNEGNQ
    61  KVVITYSSRH VYNNLTEEQK GRVAFASNFL AGDASLQIEP LKPSDEGRYT CKVKNSGRYV
   121  WSHVILKVLV RPSKPKCELE GELTEGSDLT LQCESSSGTE PIVYYWQRIR EKEGEDERLP
   181  PKSRIDYNHP GRVLLQNLTM SYSGLYQCTA GNEAGKESCV VRVTVQYVQS IGMVAGAVTG
   241  IVAGALLIFL LVWLLIRRKD KERYEEEERP NEIREDAEAP KARLVKPSSS SSGSRSSRSG
   301  SSSTRSTANS ASRSQRTLST DAAPQPGLAT QAYSLVGPEV RGSEPKKVHH ANLTKAETTP
   361  SMIPSQSRAF QTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 59 nTPM
  • blood vessel: 44 nTPM
  • colon: 39 nTPM
  • smooth muscle: 34 nTPM
  • endometrium: 28 nTPM
  • placenta: 25 nTPM

Single-cell type

  • adipocytes: 524 nCPM
  • endometrial stromal cells: 248 nCPM
  • fibroblasts: 235 nCPM
  • myosatellite cells: 234 nCPM
  • fibro-adipogenic progenitors: 231 nCPM
  • decidual stromal cells: 169 nCPM

Immune cell

  • neutrophil: 0.5 nTPM
  • basophil: 0.3 nTPM
  • MAIT T-cell: 0.2 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • cerebellum: 20 nTPM
  • hippocampal formation: 15 nTPM
  • white matter: 15 nTPM
  • medulla oblongata: 13 nTPM
  • choroid plexus: 11 nTPM
  • cerebral cortex: 9.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLMP.

Disease | AllUniProt

Conditions CLMP is implicated in, by any mechanism.

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 72 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Congenital short bowel syndrome, autosomal recessive
  • Intestinal pseudo-obstruction
  • Congenital short bowel syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLMP as an antibody target. Whether an autoantibody or antibody against CLMP could matter depends on whether native CLMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLMP is annotated at the cell surface, where native CLMP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLMP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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