Seroatlas · Human Serome Atlas

CLIP4

CAP-Gly domain-containing linker protein 4

Also known as: CLIP4_HUMAN, FLJ21069, RSNL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3C7
Gene: CLIP4
Ensembl: ENSG00000115295
Chromosome: 2
Canonical length: 705 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

705 residues, UniProt reviewed canonical sequence.

>Q8N3C7|CLIP4
     1  MTIEDLPDFP LEGNPLFGRY PFIFSASDTP VIFSISAAPM PSDCEFSFFD PNDASCQEIL
    61  FDPKTSVSEL FAILRQWVPQ VQQNIDIIGN EILKRGCNVN DRDGLTDMTL LHYTCKSGAH
   121  GIGDVETAVK FATQLIDLGA DISLRSRWTN MNALHYAAYF DVPELIRVIL KTSKPKDVDA
   181  TCSDFNFGTA LHIAAYNLCA GAVKCLLEQG ANPAFRNDKG QIPADVVPDP VDMPLEMADA
   241  AATAKEIKQM LLDAVPLSCN ISKAMLPNYD HVTGKAMLTS LGLKLGDRVV IAGQKVGTLR
   301  FCGTTEFASG QWAGIELDEP EGKNNGSVGK VQYFKCAPKY GIFAPLSKIS KAKGRRKNIT
   361  HTPSTKAAVP LIRSQKIDVA HVTSKVNTGL MTSKKDSASE STLSLPPGEE LKTVTEKDVA
   421  LLGSVSSCSS TSSLEHRQSY PKKQNAISSN KKTMSKSPSL SSRASAGLNS SATSTANNSR
   481  CEGELRLGER VLVVGQRLGT IRFFGTTNFA PGYWYGIELE KPHGKNDGSV GGVQYFSCSP
   541  RYGIFAPPSR VQRVTDSLDT LSEISSNKQN HSYPGFRRSF STTSASSQKE INRRNAFSKS
   601  KAALRRSWSS TPTAGGIEGS VKLHEGSQVL LTSSNEMGTV RYVGPTDFAS GIWLGLELRS
   661  AKGKNDGSVG DKRYFTCKPN HGVLVRPSRV TYRGINGSKL VDENC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLIP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

tongue: 37 nTPM
skeletal muscle: 33 nTPM
heart muscle: 27 nTPM
thyroid gland: 25 nTPM
esophagus: 18 nTPM
ovary: 17 nTPM

Single-cell type

podocytes: 578 nCPM
retinal pigment epithelial cells: 337 nCPM
early spermatids: 285 nCPM
myonuclei: 264 nCPM
gonadotrophs: 262 nCPM
oligodendrocytes: 251 nCPM

Immune cell

non-classical monocyte: 25 nTPM
intermediate monocyte: 15 nTPM
MAIT T-cell: 10 nTPM
memory CD8 T-cell: 6.3 nTPM
gdT-cell: 6.1 nTPM
classical monocyte: 5.7 nTPM

Brain region

white matter: 37 nTPM
pons: 29 nTPM
choroid plexus: 29 nTPM
medulla oblongata: 28 nTPM
basal ganglia: 27 nTPM
midbrain: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cytoplasmic microtubule organization

Molecular functions

microtubule plus-end binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLIP4 as an antibody target. Whether an autoantibody or antibody against CLIP4 could matter depends on whether native CLIP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLIP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLIP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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