Seroatlas · Human Serome Atlas

CLDN34

Claudin-34

Also known as: CLD34_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: H7C241
Gene: CLDN34
Ensembl: ENSG00000234469
Chromosome: X
Canonical length: 214 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be active in bicellular tight junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>H7C241|CLDN34
     1  MVWFCNSADC QFSVFALTTI GWILSSTSTG LVEWRIWYMK DTSLYPPGIA CVGIFRVCIY
    61  RRRTNSTTTK FCYRYSYQDT FLPFEISMAQ RFLLTASIFG FFGRAFNMFA LRNMSMRMFE
   121  EDTYNSFVVS GILNIAAGVF NLIAVLQNYD AVINSQGITF LPSLQMPFKP DVQEVGTAIQ
   181  VAGIGVLPML LTGMFSLFYK CPPYGQVHPG ISEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDN34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 1.6 nTPM

Expression across tissuesHPA

Tissue

testis: 1.6 nTPM
retina: 0.5 nTPM
skin: 0.2 nTPM
epididymis: 0.1 nTPM
esophagus: 0.1 nTPM
liver: 0.1 nTPM

Single-cell type

early spermatids: 11 nCPM
late primary spermatocytes: 10 nCPM
late spermatids: 8.3 nCPM
retinal ganglion cells: 3.9 nCPM
conjunctival goblet cells: 1 nCPM
prostatic hillock cells: 1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.8 nTPM
hippocampal formation: 1.1 nTPM
white matter: 1 nTPM
basal ganglia: 0.9 nTPM
choroid plexus: 0.9 nTPM
hypothalamus: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLDN34.

Disease | ImmuneIEDB

Conditions an epitope on CLDN34 was assayed in.

human immunodeficiency virus infectious disease T cell

OntologyGO

Biological processes

Molecular functions

structural molecule activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Claudin

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLDN34 as an antibody target. Whether an autoantibody or antibody against CLDN34 could matter depends on whether native CLDN34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLDN34 is annotated at the cell surface, where native CLDN34 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLDN34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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