Seroatlas · Human Serome Atlas

CLBA1

Uncharacterized protein CLBA1

Also known as: C14orf79, CLBA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96F83
Gene: CLBA1
Ensembl: ENSG00000140104
Chromosome: 14
Canonical length: 325 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable clathrin binding activity. Predicted to be involved in intracellular transport. Predicted to be part of AP-1 adaptor complex. Predicted to be active in trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q96F83|CLBA1
     1  MQGRRELGGE PLSDLQEEAA SASLRVAPER LSDDSLEWRR TCPDLLLSDG KASISMPREG
    61  GSTCTARCPD PGEHSSTWGE FEGFRESSAK SGQFSQSLEL LEGPTEPQPP RTTSAPKECS
   121  SHQPCQGGPW VTGTSAVPPS EPILSYENIL KCAFQEITVQ QAAEDVSTID HFLEISSEEK
   181  PGVERVHKLC NESRKLWRAL QSIHTTSTSQ RLWSESRCQE NFFLVLGIDA AQKNLSGGQG
   241  HIMEDCDLKE PEGLLTVSSF CLQHCKALIQ TKLSGPPGSK QGRLMTCSRF LKTPSCGGGQ
   301  HITIPRKRMF TPRKLKLTLF NSDVC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLBA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

testis: 23 nTPM
pituitary gland: 21 nTPM
thyroid gland: 17 nTPM
kidney: 16 nTPM
fallopian tube: 14 nTPM
pancreas: 14 nTPM

Single-cell type

fallopian tube ciliated cells: 54 nCPM
endometrial ciliated cells: 52 nCPM
late primary spermatocytes: 48 nCPM
respiratory ciliated cells: 44 nCPM
early spermatids: 37 nCPM
epididymal efferent duct ciliated cells: 31 nCPM

Immune cell

basophil: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0.2 nTPM
gdT-cell: 0.2 nTPM
intermediate monocyte: 0.2 nTPM

Brain region

choroid plexus: 25 nTPM
hypothalamus: 17 nTPM
midbrain: 15 nTPM
cerebral cortex: 15 nTPM
hippocampal formation: 15 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

clathrin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLBA1 as an antibody target. Whether an autoantibody or antibody against CLBA1 could matter depends on whether native CLBA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLBA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLBA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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