Seroatlas · Human Serome Atlas

CIST1

Protein CIST1

Also known as: CIST1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A2R8Y7Y5
Gene: CIST1
Canonical length: 234 aa

OverviewNCBI Gene

No narrative summary is available for CIST1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>A0A2R8Y7Y5|CIST1
     1  MACPQLPPLL LLVLVVLLKA GVNYNTPFTD IVTSENSMET SPVSSLISSP FAHSTHSSGE
    61  PPKSYSSTMS LETDSITHLS PSSSGATPTI QPSPSSTDSR MIPSSPQPET ITHPSSGSPS
   121  AELTPSSHST LPSSESLTPH WSPTSHSPGT EPLTSTDQTL EPPGPAPGDT GPRELHRNPS
   181  VVVVVCLLVS LLLIGSVVMA VRFCHRNESK FENLDEVSMG SVNDRLSFAH HLQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIST1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.67

OntologyGO

Cellular components

membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIST1 as an antibody target. Whether an autoantibody or antibody against CIST1 could matter depends on whether native CIST1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIST1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIST1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...