Seroatlas · Human Serome Atlas

CISD3

CDGSH iron-sulfur domain-containing protein 3, mitochondrial

Also known as: CISD3_HUMAN, Miner2, MiNT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7P0
Gene: CISD3
Ensembl: ENSG00000277972
Chromosome: 17
Canonical length: 127 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>P0C7P0|CISD3
     1  MRGAGAILRP AARGARDLNP RRDISSWLAQ WFPRTPARSV VALKTPIKVE LVAGKTYRWC
    61  VCGRSKKQPF CDGSHFFQRT GLSPLKFKAQ ETRMVALCTC KATQRPPYCD GTHRSERVQK
   121  AEVGSPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CISD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 22 nTPM
liver: 20 nTPM
kidney: 18 nTPM
pancreas: 17 nTPM
adrenal gland: 17 nTPM
colon: 13 nTPM

Single-cell type

parietal cells: 117 nCPM
hepatocytes: 65 nCPM
gastric chief cells: 58 nCPM
enterocytes: 52 nCPM
foveolar cells: 40 nCPM
mucous neck cells: 36 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 6.3 nTPM
cerebral cortex: 6.2 nTPM
cerebellum: 5.1 nTPM
pons: 4.7 nTPM
hypothalamus: 3.8 nTPM
medulla oblongata: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0.02
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein maturation

Molecular functions

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Iron-binding zinc finger, CDGSH type
MitoNEET, CDGSH iron-sulfur domain
Iron-binding zinc finger CDGSH type
CDGSH iron-sulfur domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CISD3 as an antibody target. Whether an autoantibody or antibody against CISD3 could matter depends on whether native CISD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CISD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CISD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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