Seroatlas · Human Serome Atlas

CISD1

CDGSH iron-sulfur domain-containing protein 1

Also known as: C10orf70, CISD1_HUMAN, MDS029, mitoNEET, ZCD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZ45
Gene: CISD1
Ensembl: ENSG00000122873
Chromosome: 10
Canonical length: 108 aa
Protein class: Enzymes, Predicted membrane proteins
Subcellular location: Mitochondria
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>Q9NZ45|CISD1
     1  MSLTSSSSVR VEWIAAVTIA AGTAAIGYLA YKRFYVKDHR NKAMINLHIQ KDNPKIVHAF
    61  DMEDLGDKAV YCRCWRSKKF PFCDGAHTKH NEETGDNVGP LIIKKKET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CISD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 77 nTPM
tongue: 47 nTPM
skeletal muscle: 44 nTPM
heart muscle: 40 nTPM
kidney: 25 nTPM
duodenum: 21 nTPM

Single-cell type

enterocytes: 501 nCPM
late spermatids: 479 nCPM
late primary spermatocytes: 400 nCPM
parietal cells: 389 nCPM
gastric progenitor cells: 346 nCPM
hepatocytes: 302 nCPM

Immune cell

myeloid DC: 7.6 nTPM
T-reg: 6.9 nTPM
memory B-cell: 6.4 nTPM
naive CD4 T-cell: 5.7 nTPM
naive CD8 T-cell: 5.7 nTPM
naive B-cell: 5.4 nTPM

Brain region

hypothalamus: 20 nTPM
cerebral cortex: 20 nTPM
choroid plexus: 18 nTPM
pons: 16 nTPM
cerebellum: 15 nTPM
medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0.02
gnomAD missense Z: 0.35
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CISD1 as an antibody target. Whether an autoantibody or antibody against CISD1 could matter depends on whether native CISD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CISD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CISD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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