Seroatlas · Human Serome Atlas

CIROZ

Ciliated left-right organizer ZP-N domains-containing protein

Also known as: CIROZ_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9H9
Gene: CIROZ
Canonical length: 823 aa

OverviewNCBI Gene

No narrative summary is available for CIROZ in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

823 residues, UniProt reviewed canonical sequence.

>Q8N9H9|CIROZ
     1  MWGSPALAWA VWLACVQPTV FPWSLSFRSD TDKPSSAAEV LTEASSCWTD TVECFSDYMT
    61  LWIPRSHVEG LRRWLARTLH LPGTWRSPDH LDSSLAKCGY FLHLASDGDF LFRVQYSACF
   121  VQKEKANYRL EIRIFQKGVM GLERSDRYIM KCPMLRSRLG QESVHCGPMF IQVSRPLPLW
   181  RDNRQTPWLL SLRGELVASL EDASLMGLYV DMNATTVTVQ SPRQGLLQRW EVLNTSAELL
   241  PLWLVSGHHA YSLEAACPPV SFQPESEVLV HIPKQRLGLV KRGSYIEETL SLRFLRVHQS
   301  NIFMVTENKD FVVVSIPAAG VLQVQRCQEV GGTPGTQAFY RVDLSLEFAE MAAPVLWTVE
   361  SFFQCVGSGT ESPASTAALR TTPSPPSPGP ETPPAGVPPA ASSQVWAAGP AAQEWLSRDL
   421  LHRPSDALAK KGLGPFLQTA KPARRGQTSA SILPRVVQAQ RGPQPPPGEA GIPGHPTPPA
   481  TLPSEPVEGV QASPWRPRPV LPTHPALTLP VSSDASSPSP PAPRPERPES LLVSGPSVTL
   541  TEGLGTVRPE QDPAKSPGSP LLLRGLSSGD VAAPEPIMGE PGQASEEFQP LARPWRATLA
   601  AEELVSHRSP GEPQETCSGT EVERPRQTGP GLPREGARGH MDLSSSEPSQ DIEGPGLSIL
   661  PARDATFSTP SVRQPDPSAW LSSGPELTGM PRVRLAAPLA VLPMEPLPPE PVRPAALLTP
   721  EASSVGGPDQ ARYLESAPGW PVGQEEWGVA HTSSPPSTQT LSLWAPTGVL LPSLVELEYP
   781  FQAGRGASLQ QELTEPTLAL SAESHRPPEL QDSVEGLSER PSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIROZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CIROZ.

Disease | AllUniProt

Conditions CIROZ is implicated in, by any mechanism.

Heterotaxy, visceral, 14, autosomal (HTX14) MIM:621080

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 19 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Heterotaxy, visceral, 14, autosomal

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

establishment of left/right asymmetry

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

CIROZ
CIROZ, beta domain
Domain of unknown function (DUF4556), Ig-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIROZ as an antibody target. Whether an autoantibody or antibody against CIROZ could matter depends on whether native CIROZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIROZ is annotated as secreted, so native CIROZ circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CIROZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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