Seroatlas · Human Serome Atlas

CIROP

Ciliated left-right organizer metallopeptidase

Also known as: CIROP_HUMAN, LMLN2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTW7
Gene
CIROP
Ensembl
ENSG00000283654
Chromosome
14
Canonical length
788 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable peptidase activity. Predicted to be involved in establishment of left/right asymmetry. Predicted to be located in membrane. Predicted to be active in cytoplasm. Implicated in visceral heterotaxy 12. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

788 residues, UniProt reviewed canonical sequence.

>A0A1B0GTW7|CIROP
     1  MLLLLLLLLL LPPLVLRVAA SRCLHDETQK SVSLLRPPFS QLPSKSRSSS LTLPSSRDPQ
    61  PLRIQSCYLG DHISDGAWDP EGEGMRGGSR ALAAVREATQ RIQAVLAVQG PLLLSRDPAQ
   121  YCHAVWGDPD SPNYHRCSLL NPGYKGESCL GAKIPDTHLR GYALWPEQGP PQLVQPDGPG
   181  VQNTDFLLYV RVAHTSKCHQ ETVSLCCPGW STAAQSQLTA ALTSWAQRRG FVMLPRLCLK
   241  LLGSSNLPTL ASQSIRITGP SVIAYAACCQ LDSEDRPLAG TIVYCAQHLT SPSLSHSDIV
   301  MATLHELLHA LGFSGQLFKK WRDCPSGFSV RENCSTRQLV TRQDEWGQLL LTTPAVSLSL
   361  AKHLGVSGAS LGVPLEEEEG LLSSHWEARL LQGSLMTATF DGAQRTRLDP ITLAAFKDSG
   421  WYQVNHSAAE ELLWGQGSGP EFGLVTTCGT GSSDFFCTGS GLGCHYLHLD KGSCSSDPML
   481  EGCRMYKPLA NGSECWKKEN GFPAGVDNPH GEIYHPQSRC FFANLTSQLL PGDKPRHPSL
   541  TPHLKEAELM GRCYLHQCTG RGAYKVQVEG SPWVPCLPGK VIQIPGYYGL LFCPRGRLCQ
   601  TNEDINAVTS PPVSLSTPDP LFQLSLELAG PPGHSLGKEQ QEGLAEAVLE ALASKGGTGR
   661  CYFHGPSITT SLVFTVHMWK SPGCQGPSVA TLHKALTLTL QKKPLEVYHG GANFTTQPSK
   721  LLVTSDHNPS MTHLRLSMGL CLMLLILVGV MGTTAYQKRA TLPVRPSASY HSPELHSTRV
   781  PVRGIREV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIROP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
0.4 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 0.4 nTPM
  • bone marrow: 0.2 nTPM
  • epididymis: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • pituitary gland: 0.2 nTPM
  • skin: 0.2 nTPM

Single-cell type

  • retinal amacrine cells: 3.5 nCPM
  • platelets: 2.8 nCPM
  • epicardial cells: 2.3 nCPM
  • oligodendrocytes: 1.3 nCPM
  • enteric stem cells: 0.6 nCPM
  • fibro-adipogenic progenitors: 0.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 1.4 nTPM
  • basal ganglia: 1.3 nTPM
  • white matter: 1.3 nTPM
  • midbrain: 1.1 nTPM
  • pons: 1.1 nTPM
  • cerebral cortex: 1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CIROP.

Disease | AllUniProt

Conditions CIROP is implicated in, by any mechanism.

  • Heterotaxy, visceral, 12, autosomal (HTX12) MIM:619702

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 21 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIROP as an antibody target. Whether an autoantibody or antibody against CIROP could matter depends on whether native CIROP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIROP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIROP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CIROP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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