Seroatlas · Human Serome Atlas

CIPC

CLOCK-interacting pacemaker

Also known as: CIPC_HUMAN, KIAA1737

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0C6
Gene: CIPC
Ensembl: ENSG00000198894
Chromosome: 14
Canonical length: 399 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of circadian rhythm. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>Q9C0C6|CIPC
     1  MERKNPSRES PRRLSAKVGK GTEMKKVARQ LGMAAAESDK DSGFSDGSSE CLSSAEQMES
    61  EDMLSALGWS REDRPRQNSK TAKNAFPTLS PMVVMKNVLV KQGSSSSQLQ SWTVQPSFEV
   121  ISAQPQLLFL HPPVPSPVSP CHTGEKKSDS RNYLPILNSY TKIAPHPGKR GLSLGPEEKG
   181  TSGVQKKICT ERLGPSLSSS EPTKAGAVPS SPSTPAPPSA KLAEDSALQG VPSLVAGGSP
   241  QTLQPVSSSH VAKAPSLTFA SPASPVCASD STLHGLESNS PLSPLSANYS SPLWAAEHLC
   301  RSPDIFSEQR QSKHRRFQNT LVVLHKSGLL EITLKTKELI RQNQATQVEL DQLKEQTQLF
   361  IEATKSRAPQ AWAKLQASLT PGSSNTGSDL EAFSDHPAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIPC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 124 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 124 nTPM
tongue: 77 nTPM
cerebellum: 43 nTPM
retina: 38 nTPM
heart muscle: 37 nTPM
midbrain: 35 nTPM

Single-cell type

fallopian tube ciliated cells: 4.7 nCPM
late spermatids: 3.1 nCPM
salivary ionocytes: 2.9 nCPM
respiratory ciliated cells: 2.7 nCPM
respiratory ionocytes: 2.5 nCPM
endometrial ciliated cells: 2.3 nCPM

Immune cell

memory B-cell: 7.9 nTPM
naive B-cell: 7.1 nTPM
neutrophil: 5.5 nTPM
NK-cell: 5.5 nTPM
myeloid DC: 5.4 nTPM
intermediate monocyte: 5.1 nTPM

Brain region

thalamus: 126 nTPM
basal ganglia: 121 nTPM
cerebellum: 112 nTPM
midbrain: 112 nTPM
medulla oblongata: 111 nTPM
white matter: 110 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.06
gnomAD missense Z: 0.75
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Clock-interacting pacemaker
Clock interacting protein circadian

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIPC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIPC as an antibody target. Whether an autoantibody or antibody against CIPC could matter depends on whether native CIPC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIPC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIPC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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