Seroatlas · Human Serome Atlas

CIMIP7

Ciliary microtubule inner protein 7

Also known as: C3orf84, CMIP7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BNL1
Gene
CIMIP7
Ensembl
ENSG00000236980
Chromosome
3
Canonical length
204 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>H3BNL1|CIMIP7
     1  MQSALVGSWH NNGFYGHYRS QFKSESAREY HLAAKPQPPA VFLQRCQEPA QRHFFSKHDN
    61  RTSFDKGPYC LLQGIGRRKD LERLWQRHTF LRWAPCEIEL RQQGPLESSY QADFRPGPGL
   121  SGLPQHLIHF VQVQPSHTRT TYQQNFCCPS QGGHYGSYKV GPQAPVTDVL PDLPGIPRPK
   181  LLQHYLHAGV SECLNWSRAL NKDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMIP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
6.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 6.9 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early spermatids: 154 nCPM
  • late spermatids: 138 nCPM
  • late primary spermatocytes: 101 nCPM
  • granulosa cells: 8.9 nCPM
  • undifferentiated spermatogonia: 8.8 nCPM
  • differentiating spermatogonia: 8.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.7 nTPM
  • hypothalamus: 1.3 nTPM
  • cerebellum: 1.1 nTPM
  • amygdala: 0.7 nTPM
  • choroid plexus: 0.7 nTPM
  • basal ganglia: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.42
gnomAD pLI
0
DepMap mean gene effect
-0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMIP7 as an antibody target. Whether an autoantibody or antibody against CIMIP7 could matter depends on whether native CIMIP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMIP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMIP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CIMIP7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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