Seroatlas · Human Serome Atlas

CIMIP6

Ciliary microtubule inner protein 6

Also known as: C2orf73, CMIP6_HUMAN, FLJ40298

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5S3
Gene: CIMIP6
Ensembl: ENSG00000177994
Chromosome: 2
Canonical length: 287 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q8N5S3|CIMIP6
     1  MEEKEDKHQQ HKIEDAAITY VSENEEIKHE EKPGKSIHHS KSHVGRGRIY YAKFINTNAR
    61  TYNEPFPYID PKKGPEIQGD WWSHGKALEP VFLPPYDSKS TQRSDFQKPS CPLVLPVKHS
   121  KMQKPSCGIV PLASPGTSAE LQNNFIEYIS FIHQYDARKT PNEPLQGKRH GAFVQREIKP
   181  GSRPTVPKGA EVLLNTPGSR SSEQSKKTEK GNSAESRMIS PGLCQQNSQE LLEPKTHLSE
   241  TDVRQAAKAC PSTPESREKT SGATQTTVGD ALFTRHKPLN PPIKKSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMIP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

testis: 46 nTPM
fallopian tube: 7.1 nTPM
choroid plexus: 3.7 nTPM
basal ganglia: 1.4 nTPM
hypothalamus: 1.4 nTPM
amygdala: 1.2 nTPM

Single-cell type

early spermatids: 1,279 nCPM
late spermatids: 738 nCPM
late primary spermatocytes: 534 nCPM
ependymal cells: 198 nCPM
respiratory ciliated cells: 165 nCPM
choroid plexus epithelial cells: 164 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 12 nTPM
medulla oblongata: 7 nTPM
midbrain: 6.2 nTPM
spinal cord: 5.5 nTPM
white matter: 3.5 nTPM
pons: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cilium

Protein domainsUniProt · Pfam · InterPro

Ciliary microtubule inner protein 6
Ciliary microtubule inner protein 6

KeywordsUniProt

Cell projection

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMIP6 as an antibody target. Whether an autoantibody or antibody against CIMIP6 could matter depends on whether native CIMIP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMIP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMIP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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