Seroatlas · Human Serome Atlas

CIMIP4

Ciliary microtubule inner protein 4

Also known as: C22orf33, CMIP4_HUMAN, EAN57, MGC35206, TEX33

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43247
Gene: CIMIP4
Ensembl: ENSG00000185264
Chromosome: 22
Canonical length: 280 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>O43247|CIMIP4
     1  MELGHGAGTT TFTRAHLNDK EGQQDLDPWK AAYSSLDTSK FKNQGLSSPQ PLPLGASAQG
    61  SSLGQCHLKE IPPPPPTAAS RDSLGMDPQS RSLKNAGSRS SSRENRATSG EGAQPCQGTD
   121  DGPSLGAQDQ RSTPTNQKGS IIPNNIRHKF GSNVVDQLVS EEQAQKAIDE VFEGQKRASS
   181  WPSRTQNPVE ISSVFSDYYD LGYNMRSNLF RGAAEETKSL MKASYTPEVI EKSVRDLEHW
   241  HGRKTDDLGR WHQKNAMNLN LQKALEEKYG ENSKSKSSKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMIP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

testis: 80 nTPM
liver: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early spermatids: 1,059 nCPM
late primary spermatocytes: 381 nCPM
late spermatids: 294 nCPM
retinal ganglion cells: 3.9 nCPM
sertoli cells: 3.7 nCPM
leydig cells: 2.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ciliary microtubule inner protein 4
Testis-expressed sequence 33 protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMIP4 as an antibody target. Whether an autoantibody or antibody against CIMIP4 could matter depends on whether native CIMIP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMIP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMIP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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