Seroatlas · Human Serome Atlas

CIMIP3

Ciliary microtubule inner protein 3

Also known as: CMIP3_HUMAN, GUCA1ANB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
X6R8D5
Gene
CIMIP3
Ensembl
ENSG00000287363
Chromosome
6
Canonical length
112 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be involved in visual perception. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>X6R8D5|CIMIP3
     1  MCKDSQKPSV PSHGPKTPSC KGVKAPHSSR PRAWKQDLEQ SLAAAYVPVV VDSKGQNPDK
    61  LRFNFYTSQY SNSLNPFYTL QKPTCGYLYR RDTDHTRKRF DVPPANLVLW RS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMIP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
114 nTPM

Expression across tissuesHPA

Tissue

  • testis: 114 nTPM
  • esophagus: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late spermatids: 1.9 nCPM
  • early spermatids: 1 nCPM
  • epididymal efferent duct absorptive cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • choroid plexus: 0 nTPM

Protein domainsUniProt · Pfam · InterPro

  • CIMIP3-like
  • Ciliary microtubule inner protein 3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMIP3 as an antibody target. Whether an autoantibody or antibody against CIMIP3 could matter depends on whether native CIMIP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMIP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMIP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CIMIP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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