Seroatlas · Human Serome Atlas

CIMIP2C

Ciliary microtubule inner protein 2C

Also known as: C2orf70, CMI2C_HUMAN, FAM166C, LOC339778

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NJV1
Gene: CIMIP2C
Ensembl: ENSG00000173557
Chromosome: 2
Canonical length: 201 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Vesicles

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>A6NJV1|CIMIP2C
     1  MASRSAGTLL TEFNAAYVPP GLMPGYQGHV PTVAFSFGAP YGTTTLKYFQ DHRNRAMEKS
    61  HTPFSQGGHF PTIFSTNPNL LLMERASTRD RWLHKPSYTR FNLDSHRSTE LTNFYQMVQQ
   121  HRKYYQDKTG TVPRVPYFAM PVREPERYPL PTVLPPLCPK KKWHLLRLAP ENLKTYQTFP
   181  SGKRVSPQER KKRDCYFEFR A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMIP2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

testis: 25 nTPM
choroid plexus: 8.2 nTPM
fallopian tube: 7.1 nTPM
stomach: 4.5 nTPM
hypothalamus: 2.4 nTPM
salivary gland: 1.8 nTPM

Single-cell type

late spermatids: 611 nCPM
early spermatids: 156 nCPM
late primary spermatocytes: 104 nCPM
fallopian tube ciliated cells: 45 nCPM
epididymal efferent duct ciliated cells: 38 nCPM
respiratory ciliated cells: 29 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 8.4 nTPM
hypothalamus: 5.9 nTPM
medulla oblongata: 4.1 nTPM
midbrain: 4.1 nTPM
spinal cord: 2.8 nTPM
pons: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ciliary microtubule inner protein 2A-C-like domain
Ciliary microtubule inner protein 2B-like
Ciliary Microtubule Inner Protein 2C

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMIP2C as an antibody target. Whether an autoantibody or antibody against CIMIP2C could matter depends on whether native CIMIP2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMIP2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMIP2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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