Seroatlas · Human Serome Atlas

CIMIP2B

Ciliary microtubule inner protein 2B

Also known as: CMI2B_HUMAN, FAM166B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MTA8
Gene: CIMIP2B
Ensembl: ENSG00000215187
Chromosome: 9
Canonical length: 275 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>A8MTA8|CIMIP2B
     1  MAVASTFIPG LNPQNPHYIP GYTGHCPLLR FSVGQTYGQV TGQLLRGPPG LAWPPVHRTL
    61  LPPIRPPRSP EVPRESLPVR RGQERLSSSM IPGYTGFVPR AQFIFAKNCS QVWAEALSDF
   121  THLHEKQGSE ELPKEAKGRK DTEKDQVPEP EGQLEEPTLE VVEQASPYSM DDRDPRKFFM
   181  SGFTGYVPCA RFLFGSSFPV LTNQALQEFG QKHSPGSAQD PKHLPPLPRT YPQNLGLLPN
   241  YGGYVPGYKF QFGHTFGHLT HDALGLSTFQ KQLLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMIP2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 475 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 475 nTPM
skeletal muscle: 299 nTPM
fallopian tube: 105 nTPM
choroid plexus: 42 nTPM
tongue: 22 nTPM
epididymis: 14 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 285 nCPM
fallopian tube ciliated cells: 236 nCPM
endometrial ciliated cells: 122 nCPM
respiratory ciliated cells: 112 nCPM
ependymal cells: 71 nCPM
adrenal cortex cells: 53 nCPM

Immune cell

T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 30 nTPM
midbrain: 20 nTPM
spinal cord: 16 nTPM
medulla oblongata: 16 nTPM
pons: 8 nTPM
hypothalamus: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

axonemal microtubule

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMIP2B as an antibody target. Whether an autoantibody or antibody against CIMIP2B could matter depends on whether native CIMIP2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMIP2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMIP2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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