Seroatlas · Human Serome Atlas

CIMIP2A

Ciliary microtubule inner protein 2A

Also known as: CMI2A_HUMAN, FAM166A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6J272
Gene: CIMIP2A
Ensembl: ENSG00000188163
Chromosome: 9
Canonical length: 317 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Located in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q6J272|CIMIP2A
     1  MTTTQKHDLF TPEPHYVPGY AGFFPQLRYQ VGNTYGRTTG QLLTDPSVQK SPCSVLSPMS
    61  KPKFIEDFSQ SKPPRVPCQD LTEPYIPHYT SLKPSKNFEI LGQLPPLEVD AQEPPGVENI
   121  PRQILLPAGF TPDTPHPPCP PGRKGDSRDL GHPVYGEEAW KSATPVCEAP RQHQLYHCQR
   181  DEYPPPARRQ QETLDVGSFQ RLPQLDHPNL IQRKAISGYA GFIPRFTWVM GLNYRDGVMQ
   241  AMDEFDKSQF LFRNPHCDLG EKLPGTHWPS NHIYSSQGLI PFYMGFIPAM QDNYALTFGN
   301  STRRAYWKEW AKRNHTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMIP2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

testis: 57 nTPM
liver: 1.8 nTPM
kidney: 1 nTPM
pituitary gland: 0.8 nTPM
epididymis: 0.6 nTPM
adipose tissue: 0.5 nTPM

Single-cell type

late spermatids: 2,031 nCPM
early spermatids: 772 nCPM
late primary spermatocytes: 97 nCPM
sertoli cells: 6.2 nCPM
epicardial cells: 4.5 nCPM
adipocytes: 3.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.6 nTPM
cerebral cortex: 0.5 nTPM
hippocampal formation: 0.4 nTPM
pons: 0.4 nTPM
medulla oblongata: 0.3 nTPM
white matter: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ciliary microtubule inner protein 2A-C-like domain
Ciliary microtubule inner protein 2B-like
Ciliary Microtubule Inner Protein 2A

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMIP2A as an antibody target. Whether an autoantibody or antibody against CIMIP2A could matter depends on whether native CIMIP2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMIP2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMIP2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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