Seroatlas · Human Serome Atlas

CIMIP1

Ciliary microtubule inner protein 1

Also known as: bA196N14.1, C20orf85, CMIP1_HUMAN, LLC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H1P6
Gene
CIMIP1
Ensembl
ENSG00000124237
Chromosome
20
Canonical length
137 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mid piece

OverviewNCBI Gene

Located in cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>Q9H1P6|CIMIP1
     1  MAQKPLSTAA AERMNLVGQD EIWKYRLKAE SEARQNWPQN WGFLTTPFEE LIKCEEDLPT
    61  PKPKIELPER FRIRPVTPVE KYIKVFPSPP VPQTTQGFIG WRSAVPGLNK CLELDDAIRS
   121  CKGAFARELC WPKQGVH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
428 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 428 nTPM
  • testis: 74 nTPM
  • lung: 25 nTPM
  • cervix: 8.1 nTPM
  • choroid plexus: 5.3 nTPM
  • endometrium: 4.8 nTPM

Single-cell type

  • fallopian tube ciliated cells: 2,555 nCPM
  • respiratory ciliated cells: 2,029 nCPM
  • epididymal efferent duct ciliated cells: 1,098 nCPM
  • endometrial ciliated cells: 1,063 nCPM
  • late spermatids: 589 nCPM
  • early spermatids: 386 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 6.4 nTPM
  • medulla oblongata: 4.8 nTPM
  • spinal cord: 4.8 nTPM
  • choroid plexus: 2.8 nTPM
  • hypothalamus: 2.2 nTPM
  • pons: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.78
gnomAD pLI
0
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMIP1 as an antibody target. Whether an autoantibody or antibody against CIMIP1 could matter depends on whether native CIMIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CIMIP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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