Seroatlas · Human Serome Atlas

CIMAP2

Ciliary microtubule-associated protein 2

Also known as: C1orf177, CMAP2_HUMAN, FLJ40201, LEM, LEXM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3ZCV2
Gene: CIMAP2
Ensembl: ENSG00000162398
Chromosome: 1
Canonical length: 418 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CIMAP2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>Q3ZCV2|CIMAP2
     1  MRESQDAAGA HGWNRVGSTA TKWFTGAPFG VQSHRFDISA VYPNWKKFST FTEAPYSTRY
    61  STQVSHIGPG TYSSKETCFS KKKLMKEVDT GWAKAQEATR LTQLPHFQYQ AIMKEKRLKE
   121  QKLGPGSYNL KDFLEQLREK PCSTRGLLSS GEVRFRGLTG NYYPGPGNYG EKGNPYTKLE
   181  ENAWNRSHSE GLMCRMSNKP HPRPHQGSGL GPGTYFFKSD LETYVARSVG TRGPYDTFSG
   241  DRSKPLPYGH YSMQKKKPRE LMNFKSFVEE LNSHHNKKHG VFSKLPRNPK TPTERIYWAN
   301  LSQCPRTLAT SGPSFWLPQE KKCKPVNQPP FLLTSKGSGA KACQMIMGSW NPVGVGRYLN
   361  TWLMETKDRR QRYRSLFLSG SKRYLSDLAR DMLMQERITP FTKGKCPPTV DYNSDPTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

esophagus: 12 nTPM
testis: 4.5 nTPM
vagina: 4.1 nTPM
cervix: 2.9 nTPM
duodenum: 1.5 nTPM
small intestine: 1.2 nTPM

Single-cell type

esophageal apical cells: 247 nCPM
late spermatids: 61 nCPM
early spermatids: 56 nCPM
nk-cells: 16 nCPM
esophageal suprabasal cells: 10 nCPM
enterocytes: 10 nCPM

Immune cell

gdT-cell: 3.7 nTPM
naive CD8 T-cell: 2.4 nTPM
NK-cell: 2 nTPM
memory CD8 T-cell: 1.9 nTPM
total PBMC: 1 nTPM
eosinophil: 0.9 nTPM

Brain region

basal ganglia: 4.2 nTPM
medulla oblongata: 1.3 nTPM
hypothalamus: 1 nTPM
pons: 1 nTPM
cerebellum: 0.8 nTPM
cerebral cortex: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Ciliary microtubule-associated protein 2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMAP2 as an antibody target. Whether an autoantibody or antibody against CIMAP2 could matter depends on whether native CIMAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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