Seroatlas · Human Serome Atlas

CHURC1

Protein Churchill

Also known as: C14orf52, CHUR_HUMAN, FLJ33064, My015

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUH1
Gene: CHURC1
Ensembl: ENSG00000258289
Chromosome: 14
Canonical length: 112 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>Q8WUH1|CHURC1
     1  MCGDCVEKEY PNRGNTCLEN GSFLLNFTGC AVCSKRDFML ITNKSLKEED GEEIVTYDHL
    61  CKNCHHVIAR HEYTFSIMDE FQEYTMLCLL CGKAEDTISI LPDDPRQMTL LF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHURC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 76 nTPM
blood vessel: 68 nTPM
thymus: 57 nTPM
ovary: 53 nTPM
tongue: 50 nTPM
liver: 49 nTPM

Single-cell type

parietal cells: 274 nCPM
late primary spermatocytes: 161 nCPM
gastric chief cells: 134 nCPM
hepatocytes: 120 nCPM
kupffer cells: 104 nCPM
early primary spermatocytes: 72 nCPM

Immune cell

neutrophil: 299 nTPM
T-reg: 243 nTPM
basophil: 203 nTPM
memory CD4 T-cell: 171 nTPM
naive CD4 T-cell: 169 nTPM
memory B-cell: 165 nTPM

Brain region

white matter: 64 nTPM
medulla oblongata: 63 nTPM
spinal cord: 55 nTPM
cerebellum: 54 nTPM
basal ganglia: 53 nTPM
thalamus: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

Transcription activator, Churchill
Churchill superfamily
Churchill protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHURC1 as an antibody target. Whether an autoantibody or antibody against CHURC1 could matter depends on whether native CHURC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHURC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHURC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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