Seroatlas · Human Serome Atlas

CHST9

Carbohydrate sulfotransferase 9

Also known as: CHST9_HUMAN, GALNAC-4-ST2, GALNAC4ST-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L1S5
Gene: CHST9
Ensembl: ENSG00000154080
Chromosome: 18
Canonical length: 443 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>Q7L1S5|CHST9
     1  MQPSEMVMNP KQVFLSVLIF GVAGLLLFMY LQVWIEEQHT GRVEKRREQK VTSGWGPVKY
    61  LRPVPRIMST EKIQEHITNQ NPKFHMPEDV REKKENLLLN SERSTRLLTK TSHSQGGDQA
   121  LSKSTGSPTE KLIEKRQGAK TVFNKFSNMN WPVDIHPLNK SLVKDNKWKK TEETQEKRRS
   181  FLQEFCKKYG GVSHHQSHLF HTVSRIYVED KHKILYCEVP KAGCSNWKRI LMVLNGLASS
   241  AYNISHNAVH YGKHLKKLDS FDLKGIYTRL NTYTKAVFVR DPMERLVSAF RDKFEHPNSY
   301  YHPVFGKAII KKYRPNACEE ALINGSGVKF KEFIHYLLDS HRPVGMDIHW EKVSKLCYPC
   361  LINYDFVGKF ETLEEDANYF LQMIGAPKEL KFPNFKDRHS SDERTNAQVV RQYLKDLTRT
   421  ERQLIYDFYY LDYLMFNYTT PFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHST9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 13 nTPM
fallopian tube: 9.7 nTPM
pancreas: 8.7 nTPM
liver: 7.6 nTPM
retina: 6.8 nTPM
testis: 6.4 nTPM

Single-cell type

respiratory deuterosomal cells: 2,151 nCPM
respiratory secretory cells: 2,028 nCPM
respiratory ciliated cells: 1,789 nCPM
respiratory basal cells: 1,717 nCPM
submucosal glandular cells: 511 nCPM
salivary basal cells: 468 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 8.7 nTPM
hippocampal formation: 6.9 nTPM
midbrain: 6.3 nTPM
cerebral cortex: 6.2 nTPM
spinal cord: 5.6 nTPM
white matter: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHST9 as an antibody target. Whether an autoantibody or antibody against CHST9 could matter depends on whether native CHST9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHST9 is annotated as secreted, so native CHST9 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CHST9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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