Seroatlas · Human Serome Atlas

CHST13

Carbohydrate sulfotransferase 13

Also known as: C4ST3, CHSTD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NET6
Gene: CHST13
Ensembl: ENSG00000180767
Chromosome: 3
Canonical length: 341 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q8NET6|CHST13
     1  MGRRCCRRRV LAAACLGAAL LLLCAAPRSL RPAFGNRALG SSWLGGEKRS PLQKLYDLDQ
    61  DPRSTLAKVH RQRRDLLNSA CSRHSRRQRL LQPEDLRHVL VDDAHGLLYC YVPKVACTNW
   121  KRVLLALSGQ ARGDPRAISA QEAHAPGRLP SLADFSPAEI NRRLRAYLAF LFVREPFERL
   181  ASAYRNKLAR PYSAAFQRRY GARIVQRLRP RALPDARARG HDVRFAEFLA YLLDPRTRRE
   241  EPFNEHWERA HALCHPCRLR YDVVGKFETL AEDAAFVLGL AGASDLSFPG PPRPRGAAAS
   301  RDLAARLFRD ISPFYQRRLF DLYKMDFLLF NYSAPSYLRL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHST13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

liver: 55 nTPM
testis: 16 nTPM
spleen: 3.1 nTPM
kidney: 3 nTPM
small intestine: 0.9 nTPM
colon: 0.7 nTPM

Single-cell type

late primary spermatocytes: 291 nCPM
early spermatids: 78 nCPM
hepatocytes: 46 nCPM
epididymal efferent duct absorptive cells: 23 nCPM
megakaryocytes: 19 nCPM
hematopoietic stem cells: 17 nCPM

Immune cell

eosinophil: 156 nTPM
classical monocyte: 33 nTPM
neutrophil: 31 nTPM
myeloid DC: 22 nTPM
intermediate monocyte: 21 nTPM
non-classical monocyte: 18 nTPM

Brain region

midbrain: 1.4 nTPM
thalamus: 1.4 nTPM
medulla oblongata: 1.1 nTPM
spinal cord: 1.1 nTPM
white matter: 0.9 nTPM
hippocampal formation: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: 1.25
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHST13 as an antibody target. Whether an autoantibody or antibody against CHST13 could matter depends on whether native CHST13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHST13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHST13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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