Seroatlas · Human Serome Atlas

CHST11

Carbohydrate sulfotransferase 11

Also known as: C4ST, C4St-1, C4ST1, CHSTB_HUMAN, HSA269537

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPF2
Gene
CHST11
Ensembl
ENSG00000171310
Chromosome
12
Canonical length
352 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q9NPF2|CHST11
     1  MKPALLEVMR MNRICRMVLA TCLGSFILVI FYFQSMLHPV MRRNPFGVDI CCRKGSRSPL
    61  QELYNPIQLE LSNTAVLHQM RRDQVTDTCR ANSATSRKRR VLTPNDLKHL VVDEDHELIY
   121  CYVPKVACTN WKRLMMVLTG RGKYSDPMEI PANEAHVSAN LKTLNQYSIP EINHRLKSYM
   181  KFLFVREPFE RLVSAYRNKF TQKYNISFHK RYGTKIIKRQ RKNATQEALR KGDDVKFEEF
   241  VAYLIDPHTQ REEPFNEHWQ TVYSLCHPCH IHYDLVGKYE TLEEDSNYVL QLAGVGSYLK
   301  FPTYAKSTRT TDEMTTEFFQ NISSEHQTQL YEVYKLDFLM FNYSVPSYLK LE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHST11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 37 nTPM
  • choroid plexus: 33 nTPM
  • appendix: 19 nTPM
  • thymus: 18 nTPM
  • placenta: 15 nTPM
  • lymph node: 14 nTPM

Single-cell type

  • neutrophils: 1,588 nCPM
  • oligodendrocyte progenitor cells: 1,558 nCPM
  • microglia: 1,430 nCPM
  • hematopoietic stem cells: 1,239 nCPM
  • choroid plexus epithelial cells: 1,058 nCPM
  • pituicytes/fscs: 1,040 nCPM

Immune cell

  • neutrophil: 16 nTPM
  • basophil: 13 nTPM
  • eosinophil: 11 nTPM
  • T-reg: 3.2 nTPM
  • gdT-cell: 3 nTPM
  • plasmacytoid DC: 2.9 nTPM

Brain region

  • choroid plexus: 132 nTPM
  • medulla oblongata: 47 nTPM
  • thalamus: 46 nTPM
  • white matter: 46 nTPM
  • pons: 45 nTPM
  • midbrain: 44 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHST11.

Disease | AllUniProt

Conditions CHST11 is implicated in, by any mechanism.

  • Osteochondrodysplasia, brachydactyly, and overlapping malformed digits (OCBMD) MIM:618167

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.41
gnomAD missense Z
1.84
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHST11 as an antibody target. Whether an autoantibody or antibody against CHST11 could matter depends on whether native CHST11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHST11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHST11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHST11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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