Seroatlas · Human Serome Atlas

CHST10

Carbohydrate sulfotransferase 10

Also known as: CHSTA_HUMAN, HNK-1ST

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43529
Gene: CHST10
Ensembl: ENSG00000115526
Chromosome: 2
Canonical length: 356 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>O43529|CHST10
     1  MHHQWLLLAA CFWVIFMFMV ASKFITLTFK DPDVYSAKQE FLFLTTMPEV RKLPEEKHIP
    61  EELKPTGKEL PDSQLVQPLV YMERLELIRN VCRDDALKNL SHTPVSKFVL DRIFVCDKHK
   121  ILFCQTPKVG NTQWKKVLIV LNGAFSSIEE IPENVVHDHE KNGLPRLSSF SDAEIQKRLK
   181  TYFKFFIVRD PFERLISAFK DKFVHNPRFE PWYRHEIAPG IIRKYRRNRT ETRGIQFEDF
   241  VRYLGDPNHR WLDLQFGDHI IHWVTYVELC APCEIMYSVI GHHETLEDDA PYILKEAGID
   301  HLVSYPTIPP GITVYNRTKV EHYFLGISKR DIRRLYARFE GDFKLFGYQK PDFLLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHST10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 29 nTPM
basal ganglia: 24 nTPM
amygdala: 20 nTPM
hippocampal formation: 17 nTPM
cerebellum: 16 nTPM
midbrain: 13 nTPM

Single-cell type

astrocytes: 29 nCPM
pituicytes/fscs: 25 nCPM
bergmann glia: 19 nCPM
oligodendrocyte progenitor cells: 17 nCPM
epididymal efferent duct absorptive cells: 16 nCPM
müller glia: 16 nCPM

Immune cell

gdT-cell: 1.3 nTPM
plasmacytoid DC: 1.1 nTPM
memory CD8 T-cell: 1 nTPM
memory B-cell: 0.8 nTPM
naive CD8 T-cell: 0.7 nTPM
naive B-cell: 0.6 nTPM

Brain region

cerebral cortex: 45 nTPM
thalamus: 35 nTPM
basal ganglia: 34 nTPM
hippocampal formation: 31 nTPM
midbrain: 31 nTPM
amygdala: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.98
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

sulfotransferase activity
HNK-1 sulfotransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHST10 as an antibody target. Whether an autoantibody or antibody against CHST10 could matter depends on whether native CHST10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHST10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHST10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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