Seroatlas · Human Serome Atlas

CHRM5

Muscarinic acetylcholine receptor M5

Also known as: ACM5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08912
Gene
CHRM5
Ensembl
ENSG00000184984
Chromosome
15
Canonical length
532 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

532 residues, UniProt reviewed canonical sequence.

>P08912|CHRM5
     1  MEGDSYHNAT TVNGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL VMISFKVNSQ
    61  LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS LACDLWLALD YVASNASVMN
   121  LLVISFDRYF SITRPLTYRA KRTPKRAGIM IGLAWLISFI LWAPAILCWQ YLVGKRTVPL
   181  DECQIQFLSE PTITFGTAIA AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVTKAE
   241  KRKPAHRALF RSCLRCPRPT LAQRERNQAS WSSSRRSTST TGKPSQATGP SANWAKAEQL
   301  TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE ETEETFVKAE TEKSDYDTPN
   361  YLLSPAAAHR PKSQKCVAYK FRLVVKADGN QETNNGCHKV KIMPCPFPVA KEPSTKGLNP
   421  NPSHQMTKRK RVVLVKERKA AQTLSAILLA FIITWTPYNI MVLVSTFCDK CVPVTLWHLG
   481  YWLCYVNSTV NPICYALCNR TFRKTFKMLL LCRWKKKKVE EKLYWQGNSK LP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHRM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
7.1 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 7.1 nTPM
  • midbrain: 2.6 nTPM
  • hypothalamus: 1.9 nTPM
  • placenta: 1.4 nTPM
  • testis: 1.3 nTPM
  • hippocampal formation: 1.2 nTPM

Single-cell type

  • epicardial cells: 205 nCPM
  • oligodendrocytes: 89 nCPM
  • cardiomyocytes: 78 nCPM
  • retinal bipolar cells: 69 nCPM
  • adipocytes: 61 nCPM
  • other brain neurons: 44 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • neutrophil: 0.4 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • hypothalamus: 43 nTPM
  • white matter: 30 nTPM
  • medulla oblongata: 23 nTPM
  • midbrain: 22 nTPM
  • pons: 22 nTPM
  • thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
1.2
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHRM5 as an antibody target. Whether an autoantibody or antibody against CHRM5 could matter depends on whether native CHRM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHRM5 is annotated at the cell surface, where native CHRM5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CHRM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHRM5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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