Seroatlas · Human Serome Atlas

CHRDL2

Chordin-like protein 2

Also known as: BNF1, CRDL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6WN34
Gene: CHRDL2
Ensembl: ENSG00000054938
Chromosome: 11
Canonical length: 429 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>Q6WN34|CHRDL2
     1  MVPEVRVLSS LLGLALLWFP LDSHARARPD MFCLFHGKRY SPGESWHPYL EPQGLMYCLR
    61  CTCSEGAHVS CYRLHCPPVH CPQPVTEPQQ CCPKCVEPHT PSGLRAPPKS CQHNGTMYQH
   121  GEIFSAHELF PSRLPNQCVL CSCTEGQIYC GLTTCPEPGC PAPLPLPDSC CQACKDEASE
   181  QSDEEDSVQS LHGVRHPQDP CSSDAGRKRG PGTPAPTGLS APLSFIPRHF RPKGAGSTTV
   241  KIVLKEKHKK ACVHGGKTYS HGEVWHPAFR AFGPLPCILC TCEDGRQDCQ RVTCPTEYPC
   301  RHPEKVAGKC CKICPEDKAD PGHSEISSTR CPKAPGRVLV HTSVSPSPDN LRRFALEHEA
   361  SDLVEIYLWK LVKGIFHLTQ IKKVRKQDFQ KEAQHFRLLA GPHEGHWNVF LAQTLELKVT
   421  ASPDKVTKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHRDL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 118 nTPM

Expression across tissuesHPA

Tissue

endometrium: 118 nTPM
smooth muscle: 114 nTPM
appendix: 109 nTPM
gallbladder: 99 nTPM
colon: 84 nTPM
stomach: 58 nTPM

Single-cell type

breast lactating cells: 2,090 nCPM
myosatellite cells: 97 nCPM
hepatocytes: 83 nCPM
late primary spermatocytes: 45 nCPM
smooth muscle cells: 17 nCPM
early spermatids: 14 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

spinal cord: 5.1 nTPM
medulla oblongata: 2.7 nTPM
hypothalamus: 2 nTPM
pons: 1.8 nTPM
midbrain: 1.7 nTPM
amygdala: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 1.14
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

BMP binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHRDL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GDF5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHRDL2 as an antibody target. Whether an autoantibody or antibody against CHRDL2 could matter depends on whether native CHRDL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHRDL2 is annotated as secreted, so native CHRDL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CHRDL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...