Seroatlas · Human Serome Atlas

CHRDL1

Chordin-like protein 1

Also known as: CHL, CRDL1_HUMAN, MGC1, NRLN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BU40
Gene
CHRDL1
Ensembl
ENSG00000101938
Chromosome
X
Canonical length
456 aa
Protein class
Disease related genes, Human disease related genes, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>Q9BU40|CHRDL1
     1  MRKKWKMGGM KYIFSLLFFL LLEGGKTEQV KHSETYCMFQ DKKYRVGERW HPYLEPYGLV
    61  YCVNCICSEN GNVLCSRVRC PNVHCLSPVH IPHLCCPRCP DSLPPVNNKV TSKSCEYNGT
   121  TYQHGELFVA EGLFQNRQPN QCTQCSCSEG NVYCGLKTCP KLTCAFPVSV PDSCCRVCRG
   181  DGELSWEHSD GDIFRQPANR EARHSYHRSH YDPPPSRQAG GLSRFPGARS HRGALMDSQQ
   241  ASGTIVQIVI NNKHKHGQVC VSNGKTYSHG ESWHPNLRAF GIVECVLCTC NVTKQECKKI
   301  HCPNRYPCKY PQKIDGKCCK VCPGKKAKEL PGQSFDNKGY FCGEETMPVY ESVFMEDGET
   361  TRKIALETER PPQVEVHVWT IRKGILQHFH IEKISKRMFE ELPHFKLVTR TTLSQWKIFT
   421  EGEAQISQMC SSRVCRTELE DLVKVLYLER SEKGHC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHRDL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
211 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 211 nTPM
  • adipose tissue: 177 nTPM
  • prostate: 133 nTPM
  • endometrium: 108 nTPM
  • smooth muscle: 95 nTPM
  • parathyroid gland: 80 nTPM

Single-cell type

  • müller glia: 115 nCPM
  • lymphatic endothelial cells: 110 nCPM
  • adipocytes: 90 nCPM
  • fibroblasts: 79 nCPM
  • pituitary stem cells: 78 nCPM
  • fibro-adipogenic progenitors: 60 nCPM

Immune cell

  • plasmacytoid DC: 0.4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • basal ganglia: 26 nTPM
  • cerebral cortex: 22 nTPM
  • cerebellum: 13 nTPM
  • amygdala: 11 nTPM
  • hippocampal formation: 10 nTPM
  • choroid plexus: 9.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHRDL1.

Disease | AllUniProt

Conditions CHRDL1 is implicated in, by any mechanism.

Disease | GeneticClinVar

22 pathogenic / likely-pathogenic of 166 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Megalocornea
  • Isolated congenital megalocornea
  • Corneal disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.22
gnomAD missense Z
0.45
DepMap mean gene effect
0.15
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHRDL1 as an antibody target. Whether an autoantibody or antibody against CHRDL1 could matter depends on whether native CHRDL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHRDL1 is annotated as secreted, so native CHRDL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CHRDL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHRDL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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