CHIC2
Cysteine-rich hydrophobic domain-containing protein 2
Also known as: BTL, CHIC2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UKJ5
- Gene
- CHIC2
- Ensembl
- ENSG00000109220
- Chromosome
- 4
- Canonical length
- 165 aa
- Protein class
- Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Vesicles,Plasma membrane
OverviewNCBI Gene
This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
165 residues, UniProt reviewed canonical sequence.
>Q9UKJ5|CHIC2
1 MADFDEIYEE EEDEERALEE QLLKYSPDPV VVRGSGHVTV FGLSNKFESE FPSSLTGKVA
61 PEEFKASINR VNSCLKKNLP VNVRWLLCGC LCCCCTLGCS MWPVICLSKR TRRSIEKLLE
121 WENNRLYHKL CLHWRLSKRK CETNNMMEYV ILIEFLPKTP IFRPDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CHIC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 39 nTPM
Expression across tissuesHPA
Tissue
- testis: 39 nTPM
- skin: 28 nTPM
- esophagus: 28 nTPM
- bone marrow: 26 nTPM
- adipose tissue: 21 nTPM
- thymus: 20 nTPM
Single-cell type
- neutrophils: 631 nCPM
- esophageal apical cells: 394 nCPM
- basal keratinocytes: 295 nCPM
- suprabasal keratinocytes: 288 nCPM
- neutrophil progenitors: 258 nCPM
- ocular epithelial cells: 201 nCPM
Immune cell
- basophil: 366 nTPM
- neutrophil: 326 nTPM
- eosinophil: 172 nTPM
- T-reg: 82 nTPM
- classical monocyte: 79 nTPM
- total PBMC: 78 nTPM
Brain region
- cerebellum: 28 nTPM
- choroid plexus: 27 nTPM
- cerebral cortex: 21 nTPM
- thalamus: 21 nTPM
- white matter: 21 nTPM
- hypothalamus: 21 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.58
- gnomAD pLI
- 0.54
- gnomAD missense Z
- 1.47
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CHIC2 as an antibody target. Whether an autoantibody or antibody against CHIC2 could matter depends on whether native CHIC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CHIC2 is annotated at the cell surface, where native CHIC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CHIC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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