Seroatlas · Human Serome Atlas

CHIC1

Cysteine-rich hydrophobic domain-containing protein 1

Also known as: BRX, CHIC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VXU3
Gene: CHIC1
Ensembl: ENSG00000204116
Chromosome: X
Canonical length: 224 aa
Protein class: Predicted membrane proteins
Subcellular location: Nuclear speckles,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a cysteine-rich hydrophobic (CHIC) domain-containing protein, and is one of the few protein-coding genes found near the X-inactivation center. Studies in mouse indicate that the mouse ortholog of this gene is subject to X-inactivation in mouse. Experiments with other CHIC domain-containing family members show that the cysteine residues are palmitoylated post-translationally, resulting in membrane association. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q5VXU3|CHIC1
     1  MSILLPNMAE FDTISELEEE EEEEAATSSS SPSSSSSVSG PDDDEEDEEE EEEEEEEEEE
    61  EEEEEEEEAP PPPRVVSEEH LRRYAPDPVL VRGAGHITVF GLSNKFDTEF PSVLTGKVAP
   121  EEFKTSIGRV NACLKKALPV NVKWLLCGCL CCCCTLGCSL WPVICLNKRT RRSIQKLIEW
   181  ENNRLYHKLA LHWKLTKRKC ETSNMMEYVI LIEFLPKYPI FRPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHIC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 8 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 8 nTPM
cerebellum: 7.2 nTPM
hypothalamus: 6.5 nTPM
adrenal gland: 6.4 nTPM
cervix: 6.4 nTPM
spinal cord: 6 nTPM

Single-cell type

somatotrophs: 146 nCPM
thyrotrophs: 143 nCPM
lactotrophs: 134 nCPM
corticotrophs: 117 nCPM
bergmann glia: 115 nCPM
pituicytes/fscs: 110 nCPM

Immune cell

MAIT T-cell: 0.7 nTPM
gdT-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM

Brain region

cerebral cortex: 20 nTPM
hypothalamus: 18 nTPM
pons: 17 nTPM
thalamus: 17 nTPM
medulla oblongata: 16 nTPM
spinal cord: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHIC1.

Disease | ImmuneIEDB

Conditions an epitope on CHIC1 was assayed in.

Chagas disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.85
gnomAD missense Z: 0.59
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHIC1 as an antibody target. Whether an autoantibody or antibody against CHIC1 could matter depends on whether native CHIC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHIC1 is annotated at the cell surface, where native CHIC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CHIC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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