Seroatlas · Human Serome Atlas

CHDH

Choline dehydrogenase, mitochondrial

Also known as: CHDH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NE62
Gene
CHDH
Ensembl
ENSG00000016391
Chromosome
3
Canonical length
594 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>Q8NE62|CHDH
     1  MWCLLRGLGR PGALARGALG QQQSLGARAL ASAGSESRDE YSYVVVGAGS AGCVLAGRLT
    61  EDPAERVLLL EAGPKDVLAG SKRLSWKIHM PAALVANLCD DRYNWCYHTE VQRGLDGRVL
   121  YWPRGRVWGG SSSLNAMVYV RGHAEDYERW QRQGARGWDY AHCLPYFRKA QGHELGASRY
   181  RGADGPLRVS RGKTNHPLHC AFLEATQQAG YPLTEDMNGF QQEGFGWMDM TIHEGKRWSA
   241  ACAYLHPALS RTNLKAEAET LVSRVLFEGT RAVGVEYVKN GQSHRAYASK EVILSGGAIN
   301  SPQLLMLSGI GNADDLKKLG IPVVCHLPGV GQNLQDHLEI YIQQACTRPI TLHSAQKPLR
   361  KVCIGLEWLW KFTGEGATAH LETGGFIRSQ PGVPHPDIQF HFLPSQVIDH GRVPTQQEAY
   421  QVHVGPMRGT SVGWLKLRSA NPQDHPVIQP NYLSTETDIE DFRLCVKLTR EIFAQEALAP
   481  FRGKELQPGS HIQSDKEIDA FVRAKADSAY HPSCTCKMGQ PSDPTAVVDP QTRVLGVENL
   541  RVVDASIMPS MVSGNLNAPT IMIAEKAADI IKGQPALWDK DVPVYKPRTL ATQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHDH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 35 nTPM
  • liver: 33 nTPM
  • pancreas: 16 nTPM
  • salivary gland: 14 nTPM
  • small intestine: 14 nTPM
  • basal ganglia: 11 nTPM

Single-cell type

  • tuft cells: 138 nCPM
  • proximal tubule cells: 133 nCPM
  • late spermatids: 76 nCPM
  • enteric stem cells: 70 nCPM
  • hepatocytes: 68 nCPM
  • enterocytes: 67 nCPM

Immune cell

  • basophil: 3 nTPM
  • T-reg: 1.3 nTPM
  • memory B-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 37 nTPM
  • thalamus: 35 nTPM
  • medulla oblongata: 32 nTPM
  • midbrain: 32 nTPM
  • basal ganglia: 31 nTPM
  • amygdala: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
1.02
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • FAD/NAD(P)-binding domain superfamily
  • Glucose-methanol-choline oxidoreductase, N-terminal
  • Glucose-methanol-choline oxidoreductase, C-terminal
  • Glucose-methanol-choline oxidoreductase
  • GMC oxidoreductase
  • GMC oxidoreductase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHDH as an antibody target. Whether an autoantibody or antibody against CHDH could matter depends on whether native CHDH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHDH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHDH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHDH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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