Seroatlas · Human Serome Atlas

CHCT1

CHD1 helical C-terminal domain containing protein 1

Also known as: C17orf64, CHCT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86WR6
Gene
CHCT1
Ensembl
ENSG00000141371
Chromosome
17
Canonical length
236 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q86WR6|CHCT1
     1  MEASDGQGGE GDKPLEQVTN VSCLETSSSA SPARDSLMRH AKGLDQDTFK TCKEYLRPLK
    61  KFLRKLHLPR DLPQKKKLKY MKQSLVVLGD HINTFLQHYC QAWEIKHWRK MLWRFISLFS
   121  ELEAKQLRRL YKYTKSSQPA KFLVTFCASD APERSLLADR EDSLPKLCHA WGLHSNISGM
   181  KERLSNMQTP GQGSPLPGQP RSQDHVKKDS LRELSQKPKL KRKRIKEAPE TPETEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHCT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
126 nTPM

Expression across tissuesHPA

Tissue

  • testis: 126 nTPM
  • bone marrow: 0.5 nTPM
  • spleen: 0.5 nTPM
  • adipose tissue: 0.3 nTPM
  • breast: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM

Single-cell type

  • early spermatids: 1,117 nCPM
  • late primary spermatocytes: 1,034 nCPM
  • late spermatids: 691 nCPM
  • early primary spermatocytes: 112 nCPM
  • differentiating spermatogonia: 15 nCPM
  • pdcs: 13 nCPM

Immune cell

  • plasmacytoid DC: 2.5 nTPM
  • neutrophil: 1 nTPM
  • myeloid DC: 0.8 nTPM
  • memory B-cell: 0.4 nTPM
  • classical monocyte: 0.3 nTPM
  • intermediate monocyte: 0.2 nTPM

Brain region

  • cerebral cortex: 2.4 nTPM
  • medulla oblongata: 1.6 nTPM
  • white matter: 1.6 nTPM
  • midbrain: 1.2 nTPM
  • pons: 1.2 nTPM
  • thalamus: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.84
gnomAD pLI
0
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHCT1 as an antibody target. Whether an autoantibody or antibody against CHCT1 could matter depends on whether native CHCT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHCT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHCT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHCT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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