Seroatlas · Human Serome Atlas

CHCHD7

Coiled-coil-helix-coiled-coil-helix domain-containing protein 7

Also known as: CHCH7_HUMAN, COX23, MGC2217

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BUK0
Gene
CHCHD7
Ensembl
ENSG00000170791
Chromosome
8
Canonical length
85 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Cell Junctions,Aggresome

OverviewNCBI Gene

Predicted to be involved in mitochondrial respiratory chain complex assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

85 residues, UniProt reviewed canonical sequence.

>Q9BUK0|CHCHD7
     1  MPSVTQRLRD PDINPCLSES DASTRCLDEN NYDRERCSTY FLRYKNCRRF WNSIVMQRRK
    61  NGVKPFMPTA AERDEILRAV GNMPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHCHD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 44 nTPM
  • epididymis: 43 nTPM
  • heart muscle: 38 nTPM
  • tongue: 37 nTPM
  • lymph node: 37 nTPM
  • tonsil: 36 nTPM

Single-cell type

  • hofbauer cells: 314 nCPM
  • megakaryocytes: 161 nCPM
  • breast lactating cells: 137 nCPM
  • gastric progenitor cells: 118 nCPM
  • epididymal principal cells: 105 nCPM
  • esophageal suprabasal cells: 103 nCPM

Immune cell

  • plasmacytoid DC: 63 nTPM
  • memory B-cell: 61 nTPM
  • T-reg: 60 nTPM
  • basophil: 55 nTPM
  • naive CD4 T-cell: 55 nTPM
  • eosinophil: 54 nTPM

Brain region

  • cerebellum: 29 nTPM
  • spinal cord: 25 nTPM
  • white matter: 24 nTPM
  • cerebral cortex: 21 nTPM
  • medulla oblongata: 21 nTPM
  • basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0.03
gnomAD missense Z
0.28
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHCHD7 as an antibody target. Whether an autoantibody or antibody against CHCHD7 could matter depends on whether native CHCHD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHCHD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHCHD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHCHD7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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