CHCHD5
Coiled-coil-helix-coiled-coil-helix domain-containing protein 5
Also known as: C2orf9, CHCH5_HUMAN, MGC11104, MIC14, MIX14
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BSY4
- Gene
- CHCHD5
- Ensembl
- ENSG00000125611
- Chromosome
- 2
- Canonical length
- 110 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Predicted to be involved in cellular respiration. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
110 residues, UniProt reviewed canonical sequence.
>Q9BSY4|CHCHD5
1 MQAALEVTAR YCGRELEQYG QCVAAKPESW QRDCHYLKMS IAQCTSSHPI IRQIRQACAQ
61 PFEAFEECLR QNEAAVGNCA EHMRRFLQCA EQVQPPRSPA TVEAQPLPASLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CHCHD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 66 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 66 nTPM
- liver: 53 nTPM
- kidney: 51 nTPM
- choroid plexus: 48 nTPM
- adrenal gland: 41 nTPM
- pituitary gland: 41 nTPM
Single-cell type
- late spermatids: 379 nCPM
- late primary spermatocytes: 330 nCPM
- hepatocytes: 224 nCPM
- esophageal suprabasal cells: 220 nCPM
- esophageal apical cells: 217 nCPM
- parietal cells: 179 nCPM
Immune cell
- plasmacytoid DC: 96 nTPM
- T-reg: 96 nTPM
- classical monocyte: 93 nTPM
- myeloid DC: 93 nTPM
- intermediate monocyte: 86 nTPM
- non-classical monocyte: 84 nTPM
Brain region
- thalamus: 24 nTPM
- hypothalamus: 19 nTPM
- medulla oblongata: 19 nTPM
- cerebellum: 18 nTPM
- spinal cord: 18 nTPM
- white matter: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.08
- gnomAD pLI
- 0.05
- gnomAD missense Z
- -0.42
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- CHCH
- CHCH domain
- IMS import disulfide relay-system, CHCH-CHCH-like Cx9C
- Coiled-coil-helix-coiled-coil-helix domain-containing protein
- CHCH-CHCH-like Cx9C, IMS import disulfide relay-system,
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CHCHD5 as an antibody target. Whether an autoantibody or antibody against CHCHD5 could matter depends on whether native CHCHD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CHCHD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CHCHD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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