Seroatlas · Human Serome Atlas

CHCHD1

Small ribosomal subunit protein mS37

Also known as: C10orf34, CHCH1_HUMAN, FLJ25854

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BP2
Gene: CHCHD1
Ensembl: ENSG00000172586
Chromosome: 10
Canonical length: 118 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Mitochondria,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in mitochondrial translation. Located in cytosol; mitochondrion; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>Q96BP2|CHCHD1
     1  MATPSLRGRL ARFGNPRKPV LKPNKPLILA NRVGERRREK GEATCITEMS VMMACWKQNE
    61  FRDDACRKEI QGFLDCAARA QEARKMRSIQ ETLGESGSLL PNKLNKLLQR FPNKPYLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHCHD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 60 nTPM
kidney: 60 nTPM
liver: 52 nTPM
choroid plexus: 51 nTPM
adrenal gland: 51 nTPM
heart muscle: 50 nTPM

Single-cell type

esophageal apical cells: 312 nCPM
esophageal suprabasal cells: 234 nCPM
megakaryocytes: 210 nCPM
extravillous trophoblasts: 203 nCPM
hofbauer cells: 198 nCPM
esophageal basal cells: 182 nCPM

Immune cell

plasmacytoid DC: 75 nTPM
T-reg: 65 nTPM
memory B-cell: 63 nTPM
intermediate monocyte: 55 nTPM
myeloid DC: 53 nTPM
classical monocyte: 52 nTPM

Brain region

choroid plexus: 18 nTPM
cerebellum: 14 nTPM
white matter: 14 nTPM
hypothalamus: 13 nTPM
thalamus: 13 nTPM
spinal cord: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: 0.73
DepMap mean gene effect: -0.58
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translation

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cysteine alpha-hairpin motif superfamily
CHCH
CHCH domain
Small ribosomal subunit protein mS37, metazoan

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHCHD1 as an antibody target. Whether an autoantibody or antibody against CHCHD1 could matter depends on whether native CHCHD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHCHD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHCHD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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