Seroatlas · Human Serome Atlas

CHAMP1

Chromosome alignment-maintaining phosphoprotein 1

Also known as: C13orf8, CAMP, CHAMP, CHAP1_HUMAN, ZNF828

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JM3
Gene: CHAMP1
Ensembl: ENSG00000198824
Chromosome: 13
Canonical length: 812 aa
Protein class: Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a zinc finger protein that functions as a regulator of chromosome segregation in mitosis. The encoded protein is required for correct alignment of chromosomes on the metaphase plate, and plays a role in maintaining the attachment of sister kinetochores to microtubules from opposite spindle poles. Mutations in this gene are associated with an autosomal dominant form of intellectual disability. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

812 residues, UniProt reviewed canonical sequence.

>Q96JM3|CHAMP1
     1  MEAFQELRKP SARLECDHCS FRGTDYENVQ IHMGTIHPEF CDEMDAGGLG KMIFYQKSAK
    61  LFHCHKCFFT SKMYSNVYYH ITSKHASPDK WNDKPKNQLN KETDPVKSPP LPEHQKIPCN
   121  SAEPKSIPAL SMETQKLGSV LSPESPKPTP LTPLEPQKPG SVVSPELQTP LPSPEPSKPA
   181  SVSSPEPPKS VPVCESQKLA PVPSPEPQKP APVSPESVKA TLSNPKPQKQ SHFPETLGPP
   241  SASSPESPVL AASPEPWGPS PAASPESRKS ARTTSPEPRK PSPSESPEPW KPFPAVSPEP
   301  RRPAPAVSPG SWKPGPPGSP RPWKSNPSAS SGPWKPAKPA PSVSPGPWKP IPSVSPGPWK
   361  PTPSVSSASW KSSSVSPSSW KSPPASPESW KSGPPELRKT APTLSPEHWK AVPPVSPELR
   421  KPGPPLSPEI RSPAGSPELR KPSGSPDLWK LSPDQRKTSP ASLDFPESQK SSRGGSPDLW
   481  KSSFFIEPQK PVFPETRKPG PSGPSESPKA ASDIWKPVLS IDTEPRKPAL FPEPAKTAPP
   541  ASPEARKRAL FPEPRKHALF PELPKSALFS ESQKAVELGD ELQIDAIDDQ KCDILVQEEL
   601  LASPKKLLED TLFPSSKKLK KDNQESSDAE LSSSEYIKTD LDAMDIKGQE SSSDQEQVDV
   661  ESIDFSKENK MDMTSPEQSR NVLQFTEEKE AFISEEEIAK YMKRGKGKYY CKICCCRAMK
   721  KGAVLHHLVN KHNVHSPYKC TICGKAFLLE SLLKNHVAAH GQSLLKCPRC NFESNFPRGF
   781  KKHLTHCQSR HNEEANKKLM EALEPPLEEQ QI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHAMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

tonsil: 16 nTPM
thymus: 15 nTPM
lymph node: 15 nTPM
pancreas: 14 nTPM
liver: 14 nTPM
bone marrow: 13 nTPM

Single-cell type

platelets: 54 nCPM
erythrocyte progenitors: 54 nCPM
gastric progenitor cells: 41 nCPM
monocyte progenitors: 30 nCPM
differentiating spermatogonia: 29 nCPM
megakaryocyte progenitors: 29 nCPM

Immune cell

plasmacytoid DC: 11 nTPM
basophil: 7.3 nTPM
non-classical monocyte: 5.7 nTPM
naive B-cell: 5.1 nTPM
memory B-cell: 4.9 nTPM
eosinophil: 4.1 nTPM

Brain region

cerebellum: 20 nTPM
cerebral cortex: 16 nTPM
hypothalamus: 16 nTPM
choroid plexus: 15 nTPM
midbrain: 15 nTPM
basal ganglia: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHAMP1.

Disease | GeneticClinVar

58 pathogenic / likely-pathogenic of 336 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability, autosomal dominant 40
CHAMP1-related syndrome
intellectual disability with severe speech impairment
Inborn genetic diseases
Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.99
gnomAD missense Z: 0.14
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger C2H2-type
Zinc finger C2H2 superfamily
Chromosome alignment-maintaining phosphoprotein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHAMP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHAMP1 as an antibody target. Whether an autoantibody or antibody against CHAMP1 could matter depends on whether native CHAMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHAMP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHAMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...