Seroatlas · Human Serome Atlas

CGRRF1

Cell growth regulator with RING finger domain protein 1

Also known as: CGR19, CGRF1_HUMAN, RNF197

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99675
Gene: CGRRF1
Ensembl: ENSG00000100532
Chromosome: 14
Canonical length: 332 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of cell growth. Located in endoplasmic reticulum and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

332 residues, UniProt reviewed canonical sequence.

>Q99675|CGRRF1
     1  MAAVFLVTLY EYSPLFYIAV VFTCFIVTTG LVLGWFGWDV PVILRNSEET QFSTRVFKKQ
    61  MRQVKNPFGL EITNPSSASI TTGITLTTDC LEDSLLTCYW GCSVQKLYEA LQKHVYCFRI
   121  STPQALEDAL YSEYLYQEQY FIKKDSKEEI YCQLPRDTKI EDFGTVPRSR YPLVALLTLA
   181  DEDDREIYDI ISMVSVIHIP DRTYKLSCRI LYQYLLLAQG QFHDLKQLFM SANNNFTPSN
   241  NSSSEEKNTD RSLLEKVGLS ESEVEPSEEN SKDCVVCQNG TVNWVLLPCR HTCLCDGCVK
   301  YFQQCPMCRQ FVQESFALCS QKEQDKDKPK TL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CGRRF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
basal ganglia: 18 nTPM
skeletal muscle: 18 nTPM
choroid plexus: 17 nTPM
cerebral cortex: 17 nTPM
spinal cord: 17 nTPM

Single-cell type

late primary spermatocytes: 222 nCPM
platelets: 222 nCPM
early spermatids: 127 nCPM
oocytes: 60 nCPM
bergmann glia: 58 nCPM
megakaryocytes: 56 nCPM

Immune cell

basophil: 61 nTPM
eosinophil: 22 nTPM
T-reg: 22 nTPM
memory CD8 T-cell: 20 nTPM
memory CD4 T-cell: 20 nTPM
naive CD4 T-cell: 20 nTPM

Brain region

cerebellum: 13 nTPM
white matter: 13 nTPM
spinal cord: 13 nTPM
midbrain: 11 nTPM
hypothalamus: 11 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.01
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type
Zinc finger, C3HC4 type (RING finger)
Cell growth regulator with RING finger domain protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CGRRF1 as an antibody target. Whether an autoantibody or antibody against CGRRF1 could matter depends on whether native CGRRF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CGRRF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CGRRF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...