Seroatlas · Human Serome Atlas

CGB3

Choriogonadotropin subunit beta 3

Also known as: CGB, CGB3_HUMAN, CGB5, CGB8, HCG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DN86
Gene: CGB3
Ensembl: ENSG00000104827
Chromosome: 19
Canonical length: 165 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>P0DN86|CGB3
     1  MEMFQGLLLL LLLSMGGTWA SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT
    61  MTRVLQGVLP ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC
   121  GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGPSDT PILPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CGB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

placenta: 9.3 nTPM
pituitary gland: 2.5 nTPM
pancreas: 2.2 nTPM
duodenum: 0.3 nTPM
testis: 0.3 nTPM
small intestine: 0.2 nTPM

Single-cell type

syncytiotrophoblasts: 953 nCPM
extravillous trophoblasts: 138 nCPM
migrating cytotrophoblasts: 7.6 nCPM
hofbauer cells: 2.7 nCPM
cytotrophoblasts: 1.5 nCPM
gonadotrophs: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.1 nTPM
cerebellum: 0.7 nTPM
choroid plexus: 0.6 nTPM
pons: 0.6 nTPM
white matter: 0.6 nTPM
medulla oblongata: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.1

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

hormone activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CGB3 as an antibody target. Whether an autoantibody or antibody against CGB3 could matter depends on whether native CGB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CGB3 is annotated as secreted, so native CGB3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CGB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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