Seroatlas · Human Serome Atlas

CGB2

Choriogonadotropin subunit beta variant 2

Also known as: CGB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NT52
Gene: CGB2
Ensembl: ENSG00000104818
Chromosome: 19
Canonical length: 163 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>Q6NT52|CGB2
     1  MSKGLLLLLL LSMGGTWASK EPLRPRCRPI NATLAVEKEG CPVCITVNTT ICAGYCPTMT
    61  RVLQGVLPAL PQVVCNYRDV RFESIRLPGC PRGVNPVVSY AVALSCQCAL CRRSTTDCGG
   121  PKDHPLTCDD PRFQASSSSK APPPSLPSPS RLPGPSDTPI LPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CGB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 1.4 nTPM

Expression across tissuesHPA

Tissue

testis: 1.4 nTPM
pituitary gland: 0.7 nTPM
basal ganglia: 0.5 nTPM
hippocampal formation: 0.3 nTPM
hypothalamus: 0.3 nTPM
esophagus: 0.2 nTPM

Single-cell type

syncytiotrophoblasts: 9.3 nCPM
differentiating spermatogonia: 2.2 nCPM
early primary spermatocytes: 2 nCPM
extravillous trophoblasts: 1 nCPM
hofbauer cells: 0.2 nCPM
late spermatids: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 1.4 nTPM
cerebral cortex: 1.3 nTPM
cerebellum: 1.2 nTPM
white matter: 1.2 nTPM
midbrain: 1.1 nTPM
hippocampal formation: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0.03
gnomAD missense Z: -0.63

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway

Molecular functions

hormone activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CGB2 as an antibody target. Whether an autoantibody or antibody against CGB2 could matter depends on whether native CGB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CGB2 is annotated as secreted, so native CGB2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CGB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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