Seroatlas · Human Serome Atlas

CGA

Glycoprotein hormones alpha chain

Also known as: FSHA, GLHA_HUMAN, GPA1, GPHa, GPHA1, HCG, LHA, TSHA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01215
Gene: CGA
Ensembl: ENSG00000135346
Chromosome: 6
Canonical length: 116 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>P01215|CGA
     1  MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL QCMGCCFSRA
    61  YPTPLRSKKT MLVQKNVTSE STCCVAKSYN RVTVMGGFKV ENHTACHCST CYYHKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CGA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 6,387 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 6,387 nTPM
placenta: 683 nTPM
stomach: 36 nTPM
parathyroid gland: 18 nTPM
adrenal gland: 5.4 nTPM
skeletal muscle: 4.6 nTPM

Single-cell type

syncytiotrophoblasts: 124,497 nCPM
extravillous trophoblasts: 7,171 nCPM
gonadotrophs: 4,125 nCPM
migrating cytotrophoblasts: 1,250 nCPM
cytotrophoblasts: 1,133 nCPM
somatotrophs: 423 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.6 nTPM
naive B-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM
gdT-cell: 0.3 nTPM

Brain region

medulla oblongata: 7.9 nTPM
midbrain: 7.4 nTPM
white matter: 6.8 nTPM
hypothalamus: 5.8 nTPM
pons: 5.8 nTPM
cerebellum: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0.35
gnomAD missense Z: 1.5
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CGA as an antibody target. Whether an autoantibody or antibody against CGA could matter depends on whether native CGA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CGA is annotated as secreted, so native CGA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CGA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...