Seroatlas · Human Serome Atlas

CFC1B

Cryptic family protein 1B

Also known as: CFC1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG36
Gene: CFC1B
Ensembl: ENSG00000152093
Chromosome: 2
Canonical length: 223 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to enable activin receptor binding activity and nodal binding activity. Predicted to be involved in circulatory system development; nodal signaling pathway; and regionalization. Predicted to act upstream of or within several processes, including heart development; left lung morphogenesis; and spleen development. Predicted to be active in cell surface and extracellular region. Implicated in tetralogy of Fallot and visceral heterotaxy. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>P0CG36|CFC1B
     1  MTWRHHVRLL FTVSLALQII NLGNSYQREK HNGGREEVTK VATQKHRQSP LNWTSSHFGE
    61  VTGSAEGWGP EEPLPYSWAF GEGASARPRC CRNGGTCVLG SFCVCPAHFT GRYCEHDQRR
   121  SECGALEHGA WTLRACHLCR CIFGALHCLP LQTPDRCDPK DFLASHAHGP SAGGAPSLLL
   181  LLPCALLHRL LRPDAPAHPR SLVPSVLQRE RRPCGRPGLG HRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFC1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 1.2 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 1.2 nTPM
hypothalamus: 0.6 nTPM
pancreas: 0.6 nTPM
prostate: 0.6 nTPM
cerebellum: 0.3 nTPM
basal ganglia: 0.2 nTPM

Single-cell type

retinal bipolar cells: 1.3 nCPM
fallopian tube ciliated cells: 0.4 nCPM
pancreatic islet cells: 0.3 nCPM
decidual stromal cells: 0.2 nCPM
corticotrophs: 0.1 nCPM
rod photoreceptor cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.8 nTPM
cerebral cortex: 0.6 nTPM
medulla oblongata: 0.5 nTPM
cerebellum: 0.1 nTPM
hippocampal formation: 0.1 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFC1B as an antibody target. Whether an autoantibody or antibody against CFC1B could matter depends on whether native CFC1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFC1B is annotated as secreted, so native CFC1B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CFC1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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