Seroatlas · Human Serome Atlas

CFAP99

Cilia- and flagella-associated protein 99

Also known as: CFA99_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: D6REC4
Gene: CFAP99
Ensembl: ENSG00000206113
Chromosome: 4
Canonical length: 646 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Mitotic spindle,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to be located in motile cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

646 residues, UniProt reviewed canonical sequence.

>D6REC4|CFAP99
     1  MAYYGKCIET VIEQLDKFTP KRDNPEQFLE AAATSLQALS PQKQSFVLEV LSGCLEYRKL
    61  LTVVVDAFYV EDGRLCLRVD HSRFEVICYL ATFLLEELGF QLFCNIIKSQ PVDKMCKFLR
   121  FFFNPLHLCS WIKDEWSLIY EPAHVKENWI DPLMRWQPEV QELINHLEGV SASQSSPLKT
   181  KAKVTEPKEF NLTAPRPRTI PAPEPVPVVA KPRPVPQSTY QPPKEQQQLE TVKRYNRRKA
   241  EELLLRANIE ELRCAMPRSC RERVQGSKQQ LRLQFPPRIR KTPKLTFYRP DNILVKLNTT
   301  AILREGALYQ RQVEQELQRV DKLVDGAGDF SEFFEWQKKM QAKDREEQLA ASECRRLQGK
   361  LSHEEAVLAR QSLMQENKQR VEQQKEQMAK LMLQRAERRL REDRSRKELV EQVIEGQKNA
   421  KAAQTKLAKG RQQTVQEAIE ESRGLLQRRA QAAQEEQRRR CELISQLRAL ETQPTRKGKL
   481  VDLTQIPGYG LEGEMSIVEL RERLALLKEN QRRKEEEKRD QIIQGKHTKS QELQNMVEQI
   541  SLCRAAMGRS AALRWEEKKA LAAAPAAPSQ DERVQQLRRR ISERAAERSR QAALLHVSAP
   601  RTARPKPRAQ LEAQHWLELE RSRERRLQAL QQGGSGPGPA RRLEAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP99 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
fallopian tube: 3.7 nTPM
choroid plexus: 2.4 nTPM
pituitary gland: 1.6 nTPM
lung: 1.4 nTPM
retina: 1.4 nTPM

Single-cell type

respiratory ciliated cells: 67 nCPM
ependymal cells: 54 nCPM
late primary spermatocytes: 46 nCPM
fallopian tube ciliated cells: 34 nCPM
endometrial ciliated cells: 33 nCPM
late spermatids: 28 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 14 nTPM
midbrain: 12 nTPM
medulla oblongata: 8.8 nTPM
spinal cord: 5.6 nTPM
pons: 5 nTPM
thalamus: 3.5 nTPM

OntologyGO

Cellular components

motile cilium

Protein domainsUniProt · Pfam · InterPro

Cilia- and flagella-associated protein 99

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP99 as an antibody target. Whether an autoantibody or antibody against CFAP99 could matter depends on whether native CFAP99 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP99 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP99 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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