Seroatlas · Human Serome Atlas

CFAP97D1

Sperm axonemal maintenance protein CFAP97D1

Also known as: C17orf105, CF97D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
B2RV13
Gene
CFAP97D1
Ensembl
ENSG00000231256
Chromosome
17
Canonical length
164 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Predicted to be involved in sperm axoneme assembly. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>B2RV13|CFAP97D1
     1  MNNSLDYLAY PVIVSNHRQS TTFRKKLDFG HYVSHKNRIQ IAKPTVDTKP PVAHTNHILK
    61  LSKLQGEQKK INKIEYENKQ LCQKIANAHR GPAKVDCWNE YFSKSLNRET RNRELVRITM
   121  ENQGILKRLV DRKPHYDRRA SEIDWQNSRR YIRNTTRYLL SQNE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP97D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • bone marrow: 0.4 nTPM
  • skeletal muscle: 0.4 nTPM
  • pancreas: 0.3 nTPM
  • retina: 0.3 nTPM
  • skin: 0.3 nTPM

Single-cell type

  • late spermatids: 2,393 nCPM
  • early spermatids: 1,825 nCPM
  • late primary spermatocytes: 267 nCPM
  • leydig cells: 4 nCPM
  • undifferentiated spermatogonia: 2.5 nCPM
  • sertoli cells: 2.2 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM

Brain region

  • cerebellum: 5.3 nTPM
  • cerebral cortex: 3.8 nTPM
  • hippocampal formation: 3.6 nTPM
  • basal ganglia: 3.5 nTPM
  • white matter: 3.5 nTPM
  • amygdala: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP97D1 as an antibody target. Whether an autoantibody or antibody against CFAP97D1 could matter depends on whether native CFAP97D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP97D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP97D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CFAP97D1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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